Assessment of the clinicodemographic parameters and treatment outcomes of locally advanced and metastatic lung cancer cases – A retrospective study from northeast India
Background: There are many lacunae in our current understanding of the shifting epidemiological trends of lung cancer as well as lack of data among Northeast Indian patients. Aims and Objectives: This study tried to assess the clinicodemographic and treatment outcomes of advanced lung cancer case...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Manipal College of Medical Sciences, Pokhara
2023-07-01
|
| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/53237 |
| _version_ | 1797790071804395520 |
|---|---|
| author | Satya Sadhan Sarangi Munlima Hazarika Partha S Roy Nithin D Raj Partha P Medhi Anupam Sarma |
| author_facet | Satya Sadhan Sarangi Munlima Hazarika Partha S Roy Nithin D Raj Partha P Medhi Anupam Sarma |
| author_sort | Satya Sadhan Sarangi |
| collection | DOAJ |
| description | Background: There are many lacunae in our current understanding of the shifting epidemiological trends of lung cancer as well as lack of data among Northeast Indian patients.
Aims and Objectives: This study tried to assess the clinicodemographic and treatment outcomes of advanced lung cancer cases.
Materials and Methods: This was a retrospective hospital-based study. Patients with histopathologically confirmed locally advanced and metastatic lung cancer and were registered at Dr. Bhubaneswar Borooah Cancer Institute between January and December 2017 who were included in the study. A record was made of patient demographic-, clinical-, and treatment-related parameters. Kaplan–Meier survival curves were obtained. A two-tailed P<0.05 was considered statistically significant.
Results: Majority of the patients were elderly males (median=60 years), with a history of smoking in three quarter of them. Non-small-cell lung carcinoma (94%) type was the most common histology. About 93% of patients presented with TNM stage IV disease. The most common palliative chemotherapy (CT) regimen used was taxanes and platinum doublet (n=24, 35%). With a median follow-up of 6 months (range 0–37), the median progression-free survival and overall survival were 8 months and 10 months, respectively. The median survival was significantly longer in patients younger than 60 years. (13 months; P=0.021) and in those with non-small-cell histology (10 months).
Conclusion: In this audit of resource-limited population with advanced lung cancer, palliative CT remains the mainstay of treatment. There is a further need to improve the survival of these advanced cases in a cost-effective manner. |
| first_indexed | 2024-03-13T01:59:32Z |
| format | Article |
| id | doaj.art-9d9d72ebd40b4074ba5ad5284a45ee6d |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-13T01:59:32Z |
| publishDate | 2023-07-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-9d9d72ebd40b4074ba5ad5284a45ee6d2023-07-02T05:55:00ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-07-01147182189https://doi.org/10.3126/ajms.v14i7.53237Assessment of the clinicodemographic parameters and treatment outcomes of locally advanced and metastatic lung cancer cases – A retrospective study from northeast IndiaSatya Sadhan Sarangi 0https://orcid.org/0000-0003-2868-5526Munlima Hazarika 1https://orcid.org/0000-0002-8314-6018Partha S Roy 2https://orcid.org/0000-0002-2778-1164Nithin D Raj 3https://orcid.org/0009-0005-0360-4330Partha P Medhi 4https://orcid.org/0000-0002-3997-4350Anupam Sarma 5https://orcid.org/0000-0001-8631-2651Assistant Professor, Department of Medical Oncology, Dr. Bhubaneswar Borooah Cancer Institute, Guwahati, Assam, India Professor, Department of Medical Oncology, Dr. Bhubaneswar Borooah Cancer Institute, Guwahati, Assam, India Professor, Department of Medical Oncology, Dr. Bhubaneswar Borooah Cancer Institute, Guwahati, Assam, India Assistant Professor, Department of Medical Oncology, Dr. Bhubaneswar Borooah Cancer Institute, Guwahati, Assam, India Assistant Professor, Department of Medical Oncology, Dr. Bhubaneswar Borooah Cancer Institute, Guwahati, Assam, India Professor, Department of Medical Oncology, Dr. Bhubaneswar Borooah Cancer Institute, Guwahati, Assam, India Background: There are many lacunae in our current understanding of the shifting epidemiological trends of lung cancer as well as lack of data among Northeast Indian patients. Aims and Objectives: This study tried to assess the clinicodemographic and treatment outcomes of advanced lung cancer cases. Materials and Methods: This was a retrospective hospital-based study. Patients with histopathologically confirmed locally advanced and metastatic lung cancer and were registered at Dr. Bhubaneswar Borooah Cancer Institute between January and December 2017 who were included in the study. A record was made of patient demographic-, clinical-, and treatment-related parameters. Kaplan–Meier survival curves were obtained. A two-tailed P<0.05 was considered statistically significant. Results: Majority of the patients were elderly males (median=60 years), with a history of smoking in three quarter of them. Non-small-cell lung carcinoma (94%) type was the most common histology. About 93% of patients presented with TNM stage IV disease. The most common palliative chemotherapy (CT) regimen used was taxanes and platinum doublet (n=24, 35%). With a median follow-up of 6 months (range 0–37), the median progression-free survival and overall survival were 8 months and 10 months, respectively. The median survival was significantly longer in patients younger than 60 years. (13 months; P=0.021) and in those with non-small-cell histology (10 months). Conclusion: In this audit of resource-limited population with advanced lung cancer, palliative CT remains the mainstay of treatment. There is a further need to improve the survival of these advanced cases in a cost-effective manner.https://www.nepjol.info/index.php/AJMS/article/view/53237lung cancer; treatment outcomes; northeast india; audit; clinicodemography; epidemiology |
| spellingShingle | Satya Sadhan Sarangi Munlima Hazarika Partha S Roy Nithin D Raj Partha P Medhi Anupam Sarma Assessment of the clinicodemographic parameters and treatment outcomes of locally advanced and metastatic lung cancer cases – A retrospective study from northeast India Asian Journal of Medical Sciences lung cancer; treatment outcomes; northeast india; audit; clinicodemography; epidemiology |
| title | Assessment of the clinicodemographic parameters and treatment outcomes of locally advanced and metastatic lung cancer cases – A retrospective study from northeast India |
| title_full | Assessment of the clinicodemographic parameters and treatment outcomes of locally advanced and metastatic lung cancer cases – A retrospective study from northeast India |
| title_fullStr | Assessment of the clinicodemographic parameters and treatment outcomes of locally advanced and metastatic lung cancer cases – A retrospective study from northeast India |
| title_full_unstemmed | Assessment of the clinicodemographic parameters and treatment outcomes of locally advanced and metastatic lung cancer cases – A retrospective study from northeast India |
| title_short | Assessment of the clinicodemographic parameters and treatment outcomes of locally advanced and metastatic lung cancer cases – A retrospective study from northeast India |
| title_sort | assessment of the clinicodemographic parameters and treatment outcomes of locally advanced and metastatic lung cancer cases a retrospective study from northeast india |
| topic | lung cancer; treatment outcomes; northeast india; audit; clinicodemography; epidemiology |
| url | https://www.nepjol.info/index.php/AJMS/article/view/53237 |
| work_keys_str_mv | AT satyasadhansarangi assessmentoftheclinicodemographicparametersandtreatmentoutcomesoflocallyadvancedandmetastaticlungcancercasesaretrospectivestudyfromnortheastindia AT munlimahazarika assessmentoftheclinicodemographicparametersandtreatmentoutcomesoflocallyadvancedandmetastaticlungcancercasesaretrospectivestudyfromnortheastindia AT parthasroy assessmentoftheclinicodemographicparametersandtreatmentoutcomesoflocallyadvancedandmetastaticlungcancercasesaretrospectivestudyfromnortheastindia AT nithindraj assessmentoftheclinicodemographicparametersandtreatmentoutcomesoflocallyadvancedandmetastaticlungcancercasesaretrospectivestudyfromnortheastindia AT parthapmedhi assessmentoftheclinicodemographicparametersandtreatmentoutcomesoflocallyadvancedandmetastaticlungcancercasesaretrospectivestudyfromnortheastindia AT anupamsarma assessmentoftheclinicodemographicparametersandtreatmentoutcomesoflocallyadvancedandmetastaticlungcancercasesaretrospectivestudyfromnortheastindia |