The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors
Primary brain tumors, both malignant and benign, are diagnosed in adults at an incidence rate of approximately 23 people per 100 thousand. The role of AhR in carcinogenesis has been a subject of debate, given that this protein may act as either an oncogenic protein or a tumor suppressor in different...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/8/2863 |
| _version_ | 1797570194297585664 |
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| author | Maria L. Perepechaeva Alevtina Y. Grishanova |
| author_facet | Maria L. Perepechaeva Alevtina Y. Grishanova |
| author_sort | Maria L. Perepechaeva |
| collection | DOAJ |
| description | Primary brain tumors, both malignant and benign, are diagnosed in adults at an incidence rate of approximately 23 people per 100 thousand. The role of AhR in carcinogenesis has been a subject of debate, given that this protein may act as either an oncogenic protein or a tumor suppressor in different cell types and contexts. Lately, there is growing evidence that aryl hydrocarbon receptor (AhR) plays an important part in the development of brain tumors. The role of AhR in brain tumors is complicated, depending on the type of tumor, on ligands that activate AhR, and other features of the pathological process. In this review, we summarize current knowledge about AhR in relation to brain tumors and provide an overview of AhR’s potential as a therapeutic target. |
| first_indexed | 2024-03-10T20:21:28Z |
| format | Article |
| id | doaj.art-9d9e60fb44fa4a74aad71bb9d496ddd7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:21:28Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9d9e60fb44fa4a74aad71bb9d496ddd72023-11-19T22:08:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01218286310.3390/ijms21082863The Role of Aryl Hydrocarbon Receptor (AhR) in Brain TumorsMaria L. Perepechaeva0Alevtina Y. Grishanova1Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Str. 2, 630117 Novosibirsk, RussiaInstitute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Str. 2, 630117 Novosibirsk, RussiaPrimary brain tumors, both malignant and benign, are diagnosed in adults at an incidence rate of approximately 23 people per 100 thousand. The role of AhR in carcinogenesis has been a subject of debate, given that this protein may act as either an oncogenic protein or a tumor suppressor in different cell types and contexts. Lately, there is growing evidence that aryl hydrocarbon receptor (AhR) plays an important part in the development of brain tumors. The role of AhR in brain tumors is complicated, depending on the type of tumor, on ligands that activate AhR, and other features of the pathological process. In this review, we summarize current knowledge about AhR in relation to brain tumors and provide an overview of AhR’s potential as a therapeutic target.https://www.mdpi.com/1422-0067/21/8/2863aryl hydrocarbon receptorAhRbrain tumorskynurenine pathwaytherapeutic target |
| spellingShingle | Maria L. Perepechaeva Alevtina Y. Grishanova The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors International Journal of Molecular Sciences aryl hydrocarbon receptor AhR brain tumors kynurenine pathway therapeutic target |
| title | The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors |
| title_full | The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors |
| title_fullStr | The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors |
| title_full_unstemmed | The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors |
| title_short | The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors |
| title_sort | role of aryl hydrocarbon receptor ahr in brain tumors |
| topic | aryl hydrocarbon receptor AhR brain tumors kynurenine pathway therapeutic target |
| url | https://www.mdpi.com/1422-0067/21/8/2863 |
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