The Drosophila Small Conductance Calcium-Activated Potassium Channel Negatively Regulates Nociception
Summary: Inhibition of nociceptor activity is important for the prevention of spontaneous pain and hyperalgesia. To identify the critical K+ channels that regulate nociceptor excitability, we performed a forward genetic screen using a Drosophila larval nociception paradigm. Knockdown of three K+ cha...
Main Authors: | Kia C.E. Walcott, Stephanie E. Mauthner, Asako Tsubouchi, Jessica Robertson, W. Daniel Tracey |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2018-09-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718313743 |
Similar Items
-
Larval defense against attack from parasitoid wasps requires nociceptive neurons.
by: Jessica L Robertson, et al.
Published: (2013-01-01) -
Nociceptor-Enriched Genes Required for Normal Thermal Nociception
by: Ken Honjo, et al.
Published: (2016-07-01) -
ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice
by: Shamseddin Ahmadi, et al.
Published: (2014-07-01) -
Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings
by: Gayle M. Passmore, et al.
Published: (2012-05-01) -
Slack Potassium Channels Modulate TRPA1-Mediated Nociception in Sensory Neurons
by: Fangyuan Zhou, et al.
Published: (2022-05-01)