Optimization of brain tumours irradiation determining the set-up margin
The aim of this work was to evaluate whether the excising margin of the clinical tumor volume and planning target volume correspond with calculated radiation margin based on systematic errors, and definition of radiation margins of individual brain lobes. This research was a retrospective...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
VINCA Institute of Nuclear Sciences
2022-01-01
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| Series: | Nuclear Technology and Radiation Protection |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/1451-3994/2022/1451-39942203235Z.pdf |
| Summary: | The aim of this work was to evaluate whether the excising margin of the
clinical tumor volume and planning target volume correspond with calculated
radiation margin based on systematic errors, and definition of radiation
margins of individual brain lobes. This research was a retrospective
cross-sectional study. We checked the systematic errors and calculated their
average and the size of radiation margins. The average systematic errors
were calculated in four directions: lateral, longitudinal, vertical, and
rotation. The largest average systematic error was calculated in the lateral
direction in the cerebellar area, and the error was also statistically significant(p < 0.05). In rotational direction we notice the statistically
significant difference in frontal lopbe (p = 0.037), and cerebellar area (p = 0.002). The largest safety margin, as measured by the apverage
systematic errors, is requirped for irradiation of the cerebellum. The
safety margin size of 6.94 mm was calculated according to the formula of Van
Herk. However, the smallest safety margin can be used for irradiation of the
occipital lobe of the brain, namely 4.85 mm. The linear regression results
that only cerebellar lesions affect lateral displacements. Based on our
calculation of the mean systematic errors, we estimate that the clinical
target volume - planning target volume safety margin can't be reduced
further from the current 5 mm to a size of 3 mm without the use of image
guided radiotherapy. |
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| ISSN: | 1451-3994 1452-8185 |