Role of Mechanotransduction and Tension in T Cell Function
T cell migration from blood to, and within lymphoid organs and tissue, as well as, T cell activation rely on complex biochemical signaling events. But T cell migration and activation also take place in distinct mechanical environments and lead to drastic morphological changes and reorganization of t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02638/full |
| _version_ | 1811315178693722112 |
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| author | Jérémie Rossy Jérémie Rossy Julia M. Laufer Daniel F. Legler Daniel F. Legler |
| author_facet | Jérémie Rossy Jérémie Rossy Julia M. Laufer Daniel F. Legler Daniel F. Legler |
| author_sort | Jérémie Rossy |
| collection | DOAJ |
| description | T cell migration from blood to, and within lymphoid organs and tissue, as well as, T cell activation rely on complex biochemical signaling events. But T cell migration and activation also take place in distinct mechanical environments and lead to drastic morphological changes and reorganization of the acto-myosin cytoskeleton. In this review we discuss how adhesion proteins and the T cell receptor act as mechanosensors to translate these mechanical contexts into signaling events. We further discuss how cell tension could bring a significant contribution to the regulation of T cell signaling and function. |
| first_indexed | 2024-04-13T11:25:33Z |
| format | Article |
| id | doaj.art-9da17ff215694f79a7871bcd19523614 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T11:25:33Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9da17ff215694f79a7871bcd195236142022-12-22T02:48:42ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-11-01910.3389/fimmu.2018.02638420360Role of Mechanotransduction and Tension in T Cell FunctionJérémie Rossy0Jérémie Rossy1Julia M. Laufer2Daniel F. Legler3Daniel F. Legler4Biotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, SwitzerlandDepartment of Biology, University of Konstanz, Konstanz, GermanyBiotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, SwitzerlandBiotechnology Institute Thurgau (BITg) at the University of Konstanz, Kreuzlingen, SwitzerlandDepartment of Biology, University of Konstanz, Konstanz, GermanyT cell migration from blood to, and within lymphoid organs and tissue, as well as, T cell activation rely on complex biochemical signaling events. But T cell migration and activation also take place in distinct mechanical environments and lead to drastic morphological changes and reorganization of the acto-myosin cytoskeleton. In this review we discuss how adhesion proteins and the T cell receptor act as mechanosensors to translate these mechanical contexts into signaling events. We further discuss how cell tension could bring a significant contribution to the regulation of T cell signaling and function.https://www.frontiersin.org/article/10.3389/fimmu.2018.02638/fullT cellmechanotransductiontensionadhesionmigrationTCR |
| spellingShingle | Jérémie Rossy Jérémie Rossy Julia M. Laufer Daniel F. Legler Daniel F. Legler Role of Mechanotransduction and Tension in T Cell Function Frontiers in Immunology T cell mechanotransduction tension adhesion migration TCR |
| title | Role of Mechanotransduction and Tension in T Cell Function |
| title_full | Role of Mechanotransduction and Tension in T Cell Function |
| title_fullStr | Role of Mechanotransduction and Tension in T Cell Function |
| title_full_unstemmed | Role of Mechanotransduction and Tension in T Cell Function |
| title_short | Role of Mechanotransduction and Tension in T Cell Function |
| title_sort | role of mechanotransduction and tension in t cell function |
| topic | T cell mechanotransduction tension adhesion migration TCR |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02638/full |
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