Correlation of HDL and LDL Cholesterol with Severity of Depression: A Cross-sectional Study
Introduction: Depression is one of the leading causes of morbidity worldwide. It can impact various biomarkers, including proteins, monoamines, and lipids. Lipids play a critical role in regulating cellular function by influencing transport, anchoring, and providing structural support. The prese...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2024-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/18892/65938_CE[Ra1]_F(IS)_QC&Ref(SHK_SS)_PF1(RI_OM)_PFA_NC(RI_KM)_PN(KM).pdf |
| Summary: | Introduction: Depression is one of the leading causes of
morbidity worldwide. It can impact various biomarkers, including
proteins, monoamines, and lipids. Lipids play a critical role in
regulating cellular function by influencing transport, anchoring,
and providing structural support. The present study aimed to
explore any correlation between lipid profiles and depression.
Aim: To investigate the correlation between different lipid profile
parameters (serum triglycerides, total cholesterol, serum Highdensity Lipoproteins (HDL), and Low-density Lipoproteins (LDL)
levels) and the severity of depression.
Materials and Methods: A hospital-based, cross-sectional
study was conducted at the Department of Psychiatry, Faculty
of Medicine and Health Sciences, SGT University, Gurugram,
Haryana, India, from June 2020 to June 2021. A total of 200
participants aged 18-65 years, diagnosed with depression
according to the ICD-10 classification, were enrolled. Clinical
assessments were conducted, and the Hamilton Depression
Rating Scale (HAM-D) (17 items) and Beck's Depression
Inventory II (BDI II) (21-item scale) were used. Lipid parameters
were obtained from fasting blood samples. The Wilcoxon’sMann-Whitney U test was applied to assess the association
between gender distribution and lipid profiles. Spearman's
correlation test was used to analyse the correlation between
HAM-D and BDI scores with lipid profiles. Statistical significance
was set at a p-value ≤0.05.
Results: The mean age of the participants was 36.05±11.24
years. Correlations between HAM-D levels and lipid profiles
revealed that all lipid parameters, except for HDL (which
showed a negative correlation), were positively associated with
HAM-D scores. These correlations were statistically significant
(p ≤0.05). Similarly, a positive correlation was observed between
all lipid levels and BDI scores, except for HDL, which exhibited
a negative correlation. These correlations were also statistically
significant (p≤0.05).
Conclusion: Higher levels of LDL cholesterol were found to be
associated with elevated depression rating scale scores and
increased susceptibility to depression. On the other hand, HDL
cholesterol demonstrated protective effects against depression.
Adopting a healthy lifestyle, implementing dietary measures,
and addressing stressors promptly may help prevent depressive
symptoms. |
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| ISSN: | 2249-782X 0973-709X |