Predictive Risk Factors Associated with Severe Radiation-Induced Mucositis in Nasopharyngeal or Oropharyngeal Cancer Patients: A Retrospective Study
Radiation-induced mucositis in head and neck cancer patients generates difficulties in eating and swallowing, and may influence treatment tolerance, compliance, and quality of life. However, predictive factors have not been studied in detail. Thus, the aim of this study was to describe the associati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2661 |
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| author | Yumiko Kawashita Sakiko Soutome Masahiro Umeda Toshiyuki Saito |
| author_facet | Yumiko Kawashita Sakiko Soutome Masahiro Umeda Toshiyuki Saito |
| author_sort | Yumiko Kawashita |
| collection | DOAJ |
| description | Radiation-induced mucositis in head and neck cancer patients generates difficulties in eating and swallowing, and may influence treatment tolerance, compliance, and quality of life. However, predictive factors have not been studied in detail. Thus, the aim of this study was to describe the association between pre-radiotherapy clinical factors and the incidence of severe radiation-induced mucositis in nasopharyngeal or oropharyngeal cancer patients. This retrospective study included all patients with definitive radiotherapy or chemoradiotherapy for nasopharyngeal or oropharyngeal cancer between July 2011 and June 2021 in a single center. The eligibility criteria included patients who received oral management during radiotherapy. Exclusion criteria was patients who received postoperative radiotherapy. The data were acquired from the medical records of patients. One hundred patients were included in this retrospective study. Grade 3 radiation-induced mucositis occurred in 47 patients (47%). Lymphocyte count was significantly associated with grade 3 mucositis (OR = 0.40; 95% CI = 0.19–0.86; <i>p</i> = 0.018). It is suggested that pre-radiation lower lymphocyte counts are a predictive risk factor for severe mucositis in patients who undergo definitive radiotherapy or chemoradiotherapy for nasopharyngeal or oropharyngeal cancer |
| first_indexed | 2024-03-09T20:38:05Z |
| format | Article |
| id | doaj.art-9da1dca66f704e228b91148ce2c44e6f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:38:05Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-9da1dca66f704e228b91148ce2c44e6f2023-11-23T23:06:43ZengMDPI AGBiomedicines2227-90592022-10-011010266110.3390/biomedicines10102661Predictive Risk Factors Associated with Severe Radiation-Induced Mucositis in Nasopharyngeal or Oropharyngeal Cancer Patients: A Retrospective StudyYumiko Kawashita0Sakiko Soutome1Masahiro Umeda2Toshiyuki Saito3Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8102, JapanDepartment of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8102, JapanDepartment of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8102, JapanDepartment of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8102, JapanRadiation-induced mucositis in head and neck cancer patients generates difficulties in eating and swallowing, and may influence treatment tolerance, compliance, and quality of life. However, predictive factors have not been studied in detail. Thus, the aim of this study was to describe the association between pre-radiotherapy clinical factors and the incidence of severe radiation-induced mucositis in nasopharyngeal or oropharyngeal cancer patients. This retrospective study included all patients with definitive radiotherapy or chemoradiotherapy for nasopharyngeal or oropharyngeal cancer between July 2011 and June 2021 in a single center. The eligibility criteria included patients who received oral management during radiotherapy. Exclusion criteria was patients who received postoperative radiotherapy. The data were acquired from the medical records of patients. One hundred patients were included in this retrospective study. Grade 3 radiation-induced mucositis occurred in 47 patients (47%). Lymphocyte count was significantly associated with grade 3 mucositis (OR = 0.40; 95% CI = 0.19–0.86; <i>p</i> = 0.018). It is suggested that pre-radiation lower lymphocyte counts are a predictive risk factor for severe mucositis in patients who undergo definitive radiotherapy or chemoradiotherapy for nasopharyngeal or oropharyngeal cancerhttps://www.mdpi.com/2227-9059/10/10/2661head and neck cancerradiation-induced mucositisretrospective studyrisk factor |
| spellingShingle | Yumiko Kawashita Sakiko Soutome Masahiro Umeda Toshiyuki Saito Predictive Risk Factors Associated with Severe Radiation-Induced Mucositis in Nasopharyngeal or Oropharyngeal Cancer Patients: A Retrospective Study Biomedicines head and neck cancer radiation-induced mucositis retrospective study risk factor |
| title | Predictive Risk Factors Associated with Severe Radiation-Induced Mucositis in Nasopharyngeal or Oropharyngeal Cancer Patients: A Retrospective Study |
| title_full | Predictive Risk Factors Associated with Severe Radiation-Induced Mucositis in Nasopharyngeal or Oropharyngeal Cancer Patients: A Retrospective Study |
| title_fullStr | Predictive Risk Factors Associated with Severe Radiation-Induced Mucositis in Nasopharyngeal or Oropharyngeal Cancer Patients: A Retrospective Study |
| title_full_unstemmed | Predictive Risk Factors Associated with Severe Radiation-Induced Mucositis in Nasopharyngeal or Oropharyngeal Cancer Patients: A Retrospective Study |
| title_short | Predictive Risk Factors Associated with Severe Radiation-Induced Mucositis in Nasopharyngeal or Oropharyngeal Cancer Patients: A Retrospective Study |
| title_sort | predictive risk factors associated with severe radiation induced mucositis in nasopharyngeal or oropharyngeal cancer patients a retrospective study |
| topic | head and neck cancer radiation-induced mucositis retrospective study risk factor |
| url | https://www.mdpi.com/2227-9059/10/10/2661 |
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