SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15

SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15

ABSTRACT The innate immune system is the first line of host defense against microbial infections. During virus infection, pattern recognition receptors (PRRs) are engaged to detect specific viral components, such as viral RNA or DNA, and regulate the innate immune response in the infected cells or i...

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Bibliographic Details
Main Authors: Lei Li, Jialiang Luo, Zhengyumeng Zhu, Qishan Xu, Ping Wang, Bo Chang, Di Wang, Lu Yu, Xiao Lu, Jia Zhou, Daming Zuo, Qingyun Chen
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
innate antiviral response
scavenger receptor A
TANK-binding kinase 1
ubiquitination
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02028-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02028-22

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