The Effect of Aerobic Training on Metabolic Parameters and Serum Level of Sirtuin1 in Women with Type 2 Diabetes
Abstract Background: Sirtuin-1 regulates important cellular processes, including apoptosis, cellular senescence, and metabolism. Therefore, sirtuin-1 may be a novel therapeutic target for type 2 diabetes. The aim of this study was to investigate the effect of 8 weeks aerobic training on sirtuin-1 l...
| Main Authors: | , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Arak Medical University
2016-12-01
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| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Subjects: | |
| Online Access: | http://amuj.arakmu.ac.ir/article-1-4511-en.pdf |
| Summary: | Abstract
Background: Sirtuin-1 regulates important cellular processes, including apoptosis, cellular senescence, and metabolism. Therefore, sirtuin-1 may be a novel therapeutic target for type 2 diabetes. The aim of this study was to investigate the effect of 8 weeks aerobic training on sirtuin-1 level and cardiometabolic parameters in women with type 2 diabetes.
Materials and Methods: In this semi-experimental study with pretest – posttest design, twenty diabetic women (aged 43.92±5.2 y) were randomly assigned to aerobic training or non-exercising control groups. Aerobic training program was performed 50-60 min/d, 3d/wk, for 2 months. Serum levels of sirtuin-1, body composition and metabolic parameters were assessed before and after the training period. Data were analyzed by paired T test.
Results: Adiposity indices, total cholesterol, triglyceride, LDL- cholesterol,blood glucose and insulin resistance index were significantly reduced in the intervention group compared to the control (p<0.05). Also, sirtuin-1 level was increased in the intervention group compared to the control (p<0.05).
Conclusion: These findings show that aerobic exercise is associated with an improvement in siruin-1 levels and metabolic indices in women with type 2 diabetes. |
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| ISSN: | 1735-5338 2008-644X |