Down-regulation of lncRNA LUADT1 suppresses cervical cancer cell growth by sequestering microRNA-1207-5p
Emerging evidence has proved the essential roles of long non-coding RNAs (lncRNAs) in cervical carcinoma (CC). LncRNA lung adenocarcinoma-associated transcript 1 (LUADT1) is overexpressed and plays an oncogenic role in various cancers; however, the function and clinical values of LUADT1 in CC remain...
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2022-02-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2022016 |
| _version_ | 1797635827786842112 |
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| author | Zhang Qian Zheng Jindan Liu Lili |
| author_facet | Zhang Qian Zheng Jindan Liu Lili |
| author_sort | Zhang Qian |
| collection | DOAJ |
| description | Emerging evidence has proved the essential roles of long non-coding RNAs (lncRNAs) in cervical carcinoma (CC). LncRNA lung adenocarcinoma-associated transcript 1 (LUADT1) is overexpressed and plays an oncogenic role in various cancers; however, the function and clinical values of LUADT1 in CC remain unclear. In this study we found that LUADT1 is highly expressed in CC tissues and cells. Up-regulated LUADT1 is significantly correlated with the more aggressive status and poorer survival of CC patients. In vitro studies show that LUADT1 depletion suppresses CC proliferation, and leads to cell apoptosis and cell cycle arrest. Furthermore, the in vivo xenograft mouse assay demonstrates that LUADT1 knockdown remarkably suppresses tumor growth. Mechanistically, LUADT1 binds to miR-1207-5p and inhibits miR-1207-5p expression in CC cells. Septin 9 (SEPT9) is identified as a miR-1207-5p target which is negatively regulated by LUADT1. Overexpression of SEPT9 abrogates the suppressed proliferation of CC cells induced by LUADT1 knockdown. These results demonstrate that LUADT1 sponges miR-1207-5p and consequently modulates SEPT9 expression in CC. Our study suggests the possible application of LUADT1 as a prognostic and therapeutic target to inhibit CC. |
| first_indexed | 2024-03-11T12:25:55Z |
| format | Article |
| id | doaj.art-9da4f5c407904c5ebc3ad76fc74ab22c |
| institution | Directory Open Access Journal |
| issn | 1672-9145 |
| language | English |
| last_indexed | 2024-03-11T12:25:55Z |
| publishDate | 2022-02-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj.art-9da4f5c407904c5ebc3ad76fc74ab22c2023-11-06T09:07:00ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452022-02-015432133110.3724/abbs.202201620d259ccDown-regulation of lncRNA LUADT1 suppresses cervical cancer cell growth by sequestering microRNA-1207-5pZhang Qian0Zheng Jindan1Liu Lili2[][][]Emerging evidence has proved the essential roles of long non-coding RNAs (lncRNAs) in cervical carcinoma (CC). LncRNA lung adenocarcinoma-associated transcript 1 (LUADT1) is overexpressed and plays an oncogenic role in various cancers; however, the function and clinical values of LUADT1 in CC remain unclear. In this study we found that LUADT1 is highly expressed in CC tissues and cells. Up-regulated LUADT1 is significantly correlated with the more aggressive status and poorer survival of CC patients. In vitro studies show that LUADT1 depletion suppresses CC proliferation, and leads to cell apoptosis and cell cycle arrest. Furthermore, the in vivo xenograft mouse assay demonstrates that LUADT1 knockdown remarkably suppresses tumor growth. Mechanistically, LUADT1 binds to miR-1207-5p and inhibits miR-1207-5p expression in CC cells. Septin 9 (SEPT9) is identified as a miR-1207-5p target which is negatively regulated by LUADT1. Overexpression of SEPT9 abrogates the suppressed proliferation of CC cells induced by LUADT1 knockdown. These results demonstrate that LUADT1 sponges miR-1207-5p and consequently modulates SEPT9 expression in CC. Our study suggests the possible application of LUADT1 as a prognostic and therapeutic target to inhibit CC.https://www.sciengine.com/doi/10.3724/abbs.2022016cervical cancerlung adenocarcinoma-associated transcript 1LncRNAmicroRNA-1207-5p |
| spellingShingle | Zhang Qian Zheng Jindan Liu Lili Down-regulation of lncRNA LUADT1 suppresses cervical cancer cell growth by sequestering microRNA-1207-5p Acta Biochimica et Biophysica Sinica cervical cancer lung adenocarcinoma-associated transcript 1 LncRNA microRNA-1207-5p |
| title | Down-regulation of lncRNA LUADT1 suppresses cervical cancer cell growth by sequestering microRNA-1207-5p |
| title_full | Down-regulation of lncRNA LUADT1 suppresses cervical cancer cell growth by sequestering microRNA-1207-5p |
| title_fullStr | Down-regulation of lncRNA LUADT1 suppresses cervical cancer cell growth by sequestering microRNA-1207-5p |
| title_full_unstemmed | Down-regulation of lncRNA LUADT1 suppresses cervical cancer cell growth by sequestering microRNA-1207-5p |
| title_short | Down-regulation of lncRNA LUADT1 suppresses cervical cancer cell growth by sequestering microRNA-1207-5p |
| title_sort | down regulation of lncrna luadt1 suppresses cervical cancer cell growth by sequestering microrna 1207 5p |
| topic | cervical cancer lung adenocarcinoma-associated transcript 1 LncRNA microRNA-1207-5p |
| url | https://www.sciengine.com/doi/10.3724/abbs.2022016 |
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