Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist
<p>Abstract</p> <p>Background</p> <p>The pathologic diagnosis of isolated myocarditis without pericardial involvement is uncommonly encountered in systemic onset Juvenile Idiopathic Arthritis (soJIA).</p> <p>Case</p> <p>An eleven year-old boy wit...
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| Format: | Article |
| Language: | English |
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BMC
2012-04-01
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| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | http://www.ped-rheum.com/content/10/1/8 |
| _version_ | 1818918673191010304 |
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| author | Zeft Andrew S Menon Shaji C Miller Dylan |
| author_facet | Zeft Andrew S Menon Shaji C Miller Dylan |
| author_sort | Zeft Andrew S |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The pathologic diagnosis of isolated myocarditis without pericardial involvement is uncommonly encountered in systemic onset Juvenile Idiopathic Arthritis (soJIA).</p> <p>Case</p> <p>An eleven year-old boy with soJIA died suddenly while being treated with the interleukin 1 (IL-1) receptor inhibitor, anakinra. His autopsy revealed an enlarged heart and microscopic findings were consistent with myocarditis, but not pericarditis. Viral PCR testing performed on his myocardial tissue was negative.</p> <p>Conclusion</p> <p>This case illustrates myocarditis as a fatal complication of soJIA, potentially enabled by anakinra.</p> |
| first_indexed | 2024-12-20T00:53:42Z |
| format | Article |
| id | doaj.art-9da6cec7796c404cbe6642d4533c50f9 |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-12-20T00:53:42Z |
| publishDate | 2012-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-9da6cec7796c404cbe6642d4533c50f92022-12-21T19:59:10ZengBMCPediatric Rheumatology Online Journal1546-00962012-04-01101810.1186/1546-0096-10-8Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonistZeft Andrew SMenon Shaji CMiller Dylan<p>Abstract</p> <p>Background</p> <p>The pathologic diagnosis of isolated myocarditis without pericardial involvement is uncommonly encountered in systemic onset Juvenile Idiopathic Arthritis (soJIA).</p> <p>Case</p> <p>An eleven year-old boy with soJIA died suddenly while being treated with the interleukin 1 (IL-1) receptor inhibitor, anakinra. His autopsy revealed an enlarged heart and microscopic findings were consistent with myocarditis, but not pericarditis. Viral PCR testing performed on his myocardial tissue was negative.</p> <p>Conclusion</p> <p>This case illustrates myocarditis as a fatal complication of soJIA, potentially enabled by anakinra.</p>http://www.ped-rheum.com/content/10/1/8ArthritisMyocarditisIdiopathicInterleukinJuvenile |
| spellingShingle | Zeft Andrew S Menon Shaji C Miller Dylan Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist Pediatric Rheumatology Online Journal Arthritis Myocarditis Idiopathic Interleukin Juvenile |
| title | Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist |
| title_full | Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist |
| title_fullStr | Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist |
| title_full_unstemmed | Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist |
| title_short | Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist |
| title_sort | fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist |
| topic | Arthritis Myocarditis Idiopathic Interleukin Juvenile |
| url | http://www.ped-rheum.com/content/10/1/8 |
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