Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studies
Turmeric or Curcuma longa is a natural product, whose medicinal properties have been extensively studied and a wide variety of therapeutic effects on several diseases such as neurodegenerative, hepatic and renal damage, cancer, and diabetes have been mainly attributed to its curcuminoid content. In...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-12-01
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| Series: | Journal of Nutrition & Intermediary Metabolism |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235238591730275X |
| _version_ | 1819178196979941376 |
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| author | Susana Rivera-Mancía Joyce Trujillo José Pedraza Chaverri |
| author_facet | Susana Rivera-Mancía Joyce Trujillo José Pedraza Chaverri |
| author_sort | Susana Rivera-Mancía |
| collection | DOAJ |
| description | Turmeric or Curcuma longa is a natural product, whose medicinal properties have been extensively studied and a wide variety of therapeutic effects on several diseases such as neurodegenerative, hepatic and renal damage, cancer, and diabetes have been mainly attributed to its curcuminoid content. In the last decades, diabetes mellitus has become an alarming worldwide health issue, because of the increasing number of people suffering from the disease, as well as the devastating consequences for them. In this paper, we review the current basic and clinical evidence about the potential of curcumin/curcuminoids for the treatment of diabetes mellitus, mainly by its hypoglycemic, antioxidant, and anti-inflammatory properties. The activity of curcumin (or curcuminoids) as a hypoglycemic agent or just as an adjuvant to improve the metabolic profile and to ameliorate the associated complications of diabetes mellitus, such as diabetic nephropathy and cardiopathy is discussed. The interactions between curcumin and conventional antidiabetic drugs might be explored for the therapeutic management of diabetes mellitus. Keywords: Diabetes mellitus, Curcumin, Glucose, Lipids |
| first_indexed | 2024-12-22T21:38:43Z |
| format | Article |
| id | doaj.art-9da9386cbfba486abf28544aa71c1dca |
| institution | Directory Open Access Journal |
| issn | 2352-3859 |
| language | English |
| last_indexed | 2024-12-22T21:38:43Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Nutrition & Intermediary Metabolism |
| spelling | doaj.art-9da9386cbfba486abf28544aa71c1dca2022-12-21T18:11:40ZengElsevierJournal of Nutrition & Intermediary Metabolism2352-38592018-12-01142941Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studiesSusana Rivera-Mancía0Joyce Trujillo1José Pedraza Chaverri2National Council of Science and Technology – National Institute of Cardiology Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City, 14080, MexicoNational Council of Science and Technology – Potosino Institute for Scientific and Technological Research-Consortium for Research, Innovation and Development for Arid Zones (CONACYT-IPICYT-CIIDZA), Camino a la Presa San José 2055, Lomas 4a sección, 78216, San Luis Potosí, S.L.P., MexicoDepartment of Biology, Faculty of Chemistry, National Autonomous University of Mexico (UNAM), University City, Coyoacán, Mexico City, 04510, Mexico; Corresponding author. Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico (UNAM) University City, Mexico City, 04510, Mexico.Turmeric or Curcuma longa is a natural product, whose medicinal properties have been extensively studied and a wide variety of therapeutic effects on several diseases such as neurodegenerative, hepatic and renal damage, cancer, and diabetes have been mainly attributed to its curcuminoid content. In the last decades, diabetes mellitus has become an alarming worldwide health issue, because of the increasing number of people suffering from the disease, as well as the devastating consequences for them. In this paper, we review the current basic and clinical evidence about the potential of curcumin/curcuminoids for the treatment of diabetes mellitus, mainly by its hypoglycemic, antioxidant, and anti-inflammatory properties. The activity of curcumin (or curcuminoids) as a hypoglycemic agent or just as an adjuvant to improve the metabolic profile and to ameliorate the associated complications of diabetes mellitus, such as diabetic nephropathy and cardiopathy is discussed. The interactions between curcumin and conventional antidiabetic drugs might be explored for the therapeutic management of diabetes mellitus. Keywords: Diabetes mellitus, Curcumin, Glucose, Lipidshttp://www.sciencedirect.com/science/article/pii/S235238591730275X |
| spellingShingle | Susana Rivera-Mancía Joyce Trujillo José Pedraza Chaverri Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studies Journal of Nutrition & Intermediary Metabolism |
| title | Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studies |
| title_full | Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studies |
| title_fullStr | Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studies |
| title_full_unstemmed | Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studies |
| title_short | Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studies |
| title_sort | utility of curcumin for the treatment of diabetes mellitus evidence from preclinical and clinical studies |
| url | http://www.sciencedirect.com/science/article/pii/S235238591730275X |
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