Hepatoprotector Effect of Moringa Oleifera Lam. Seeds Extract Through Decrease Liver Inflammation of Rats with Metabolic Syndrome
Background: Metabolic syndrome has been associated with chronic inflammation due to the increase of lymphocyte focus on hepatic lobular tissue. Moringa oleifera Lam. is an herbal plant that potentially reduce the inflammation process. This study aims to evaluate the effect of Moringa seed extract (M...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Interna Publishing
2022-12-01
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| Series: | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
| Subjects: | |
| Online Access: | https://www.ina-jghe.com/index.php/jghe/article/view/848 |
| _version_ | 1827932446445797376 |
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| author | Bastomy Eka Rezkita Ina Agustin Pertiwi Ismi Cahya Dhelima Dyah Ratna Budiani Steven Irving |
| author_facet | Bastomy Eka Rezkita Ina Agustin Pertiwi Ismi Cahya Dhelima Dyah Ratna Budiani Steven Irving |
| author_sort | Bastomy Eka Rezkita |
| collection | DOAJ |
| description | Background: Metabolic syndrome has been associated with chronic inflammation due to the increase of lymphocyte focus on hepatic lobular tissue. Moringa oleifera Lam. is an herbal plant that potentially reduce the inflammation process. This study aims to evaluate the effect of Moringa seed extract (MSE) on hepatic lobular
inflammation in rats with hepatic tissue metabolic syndrome (MetS).
Method: Twenty-four male Wistar rats (n = 24) were assigned into four groups: one control group (C) and three MetS groups, fed with a high-fat, high-fructose diet (HFHFD) daily for 53 days. After 53 days, respectively, MetS 2 and MetS 3 groups were given 150 and 200 mg/kg MSE. After 28 days of MSE administration, the rats were sacrificed, and then hepatic lobular inflammation measured with lobular inflammation score. The effect of MSE on hepatic lobular inflammation was analyzed with Kruskal-Wallis and Mann-Whitney test.
Results: There was a significant difference in hepatic lobular inflammation between four groups (p = 0.000). Mann-Whitney showed a significant difference between C vs. MetS 1, MetS 1 vs. MetS 2, and MetS 1 vs. MetS 3 (p = 0.000), but not significant C vs. MetS 2 (p = 0.364), C vs. MetS 3 (p = 0.109), MetS 2 vs. MetS 3 (p = 0.533).
Conclusion: MSE at the dose of 150 mg/kg and 200 mg/kg significantly reduces lobular inflammation in hepatic tissue of MetS rats. |
| first_indexed | 2024-03-13T07:09:57Z |
| format | Article |
| id | doaj.art-9daadbabd42b4e4a8afdda13483ef7dd |
| institution | Directory Open Access Journal |
| issn | 1411-4801 2302-8181 |
| language | English |
| last_indexed | 2024-03-13T07:09:57Z |
| publishDate | 2022-12-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
| spelling | doaj.art-9daadbabd42b4e4a8afdda13483ef7dd2023-06-06T04:45:36ZengInterna PublishingThe Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy1411-48012302-81812022-12-0123317417910.24871/2332022174-179803Hepatoprotector Effect of Moringa Oleifera Lam. Seeds Extract Through Decrease Liver Inflammation of Rats with Metabolic SyndromeBastomy Eka Rezkita0Ina Agustin Pertiwi1Ismi Cahya Dhelima2Dyah Ratna Budiani3Steven Irving4Faculty of Medicine, Universitas Sebelas Maret, SurakartaFaculty of Medicine, Universitas Sebelas Maret, SurakartaFaculty of Medicine, Universitas Sebelas Maret, SurakartaFaculty of Medicine, Universitas Sebelas Maret, SurakartaFaculty of Medicine, Universitas Sebelas Maret, SurakartaBackground: Metabolic syndrome has been associated with chronic inflammation due to the increase of lymphocyte focus on hepatic lobular tissue. Moringa oleifera Lam. is an herbal plant that potentially reduce the inflammation process. This study aims to evaluate the effect of Moringa seed extract (MSE) on hepatic lobular inflammation in rats with hepatic tissue metabolic syndrome (MetS). Method: Twenty-four male Wistar rats (n = 24) were assigned into four groups: one control group (C) and three MetS groups, fed with a high-fat, high-fructose diet (HFHFD) daily for 53 days. After 53 days, respectively, MetS 2 and MetS 3 groups were given 150 and 200 mg/kg MSE. After 28 days of MSE administration, the rats were sacrificed, and then hepatic lobular inflammation measured with lobular inflammation score. The effect of MSE on hepatic lobular inflammation was analyzed with Kruskal-Wallis and Mann-Whitney test. Results: There was a significant difference in hepatic lobular inflammation between four groups (p = 0.000). Mann-Whitney showed a significant difference between C vs. MetS 1, MetS 1 vs. MetS 2, and MetS 1 vs. MetS 3 (p = 0.000), but not significant C vs. MetS 2 (p = 0.364), C vs. MetS 3 (p = 0.109), MetS 2 vs. MetS 3 (p = 0.533). Conclusion: MSE at the dose of 150 mg/kg and 200 mg/kg significantly reduces lobular inflammation in hepatic tissue of MetS rats.https://www.ina-jghe.com/index.php/jghe/article/view/848metabolic syndromemoringa oleifera lam. seeds extracthepatic lobularinflammation |
| spellingShingle | Bastomy Eka Rezkita Ina Agustin Pertiwi Ismi Cahya Dhelima Dyah Ratna Budiani Steven Irving Hepatoprotector Effect of Moringa Oleifera Lam. Seeds Extract Through Decrease Liver Inflammation of Rats with Metabolic Syndrome The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy metabolic syndrome moringa oleifera lam. seeds extract hepatic lobular inflammation |
| title | Hepatoprotector Effect of Moringa Oleifera Lam. Seeds Extract Through Decrease Liver Inflammation of Rats with Metabolic Syndrome |
| title_full | Hepatoprotector Effect of Moringa Oleifera Lam. Seeds Extract Through Decrease Liver Inflammation of Rats with Metabolic Syndrome |
| title_fullStr | Hepatoprotector Effect of Moringa Oleifera Lam. Seeds Extract Through Decrease Liver Inflammation of Rats with Metabolic Syndrome |
| title_full_unstemmed | Hepatoprotector Effect of Moringa Oleifera Lam. Seeds Extract Through Decrease Liver Inflammation of Rats with Metabolic Syndrome |
| title_short | Hepatoprotector Effect of Moringa Oleifera Lam. Seeds Extract Through Decrease Liver Inflammation of Rats with Metabolic Syndrome |
| title_sort | hepatoprotector effect of moringa oleifera lam seeds extract through decrease liver inflammation of rats with metabolic syndrome |
| topic | metabolic syndrome moringa oleifera lam. seeds extract hepatic lobular inflammation |
| url | https://www.ina-jghe.com/index.php/jghe/article/view/848 |
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