Surgery for Colorectal Cancer: A Trigger for Liver Metastases Development? New Insights into the Underlying Mechanisms
Surgery is a crucial intervention and provides the best chance of cure for patients with colorectal cancer. Experimental and clinical evidence, however, suggests that paradoxically surgery itself may precipitate or accelerate tumor recurrence and/or liver metastasis development. This review addresse...
| Principais autores: | , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
MDPI AG
2021-02-01
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| coleção: | Biomedicines |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/2227-9059/9/2/177 |
| _version_ | 1827600936189558784 |
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| author | Simran Grewal Steven J. Oosterling Marjolein van Egmond |
| author_facet | Simran Grewal Steven J. Oosterling Marjolein van Egmond |
| author_sort | Simran Grewal |
| collection | DOAJ |
| description | Surgery is a crucial intervention and provides the best chance of cure for patients with colorectal cancer. Experimental and clinical evidence, however, suggests that paradoxically surgery itself may precipitate or accelerate tumor recurrence and/or liver metastasis development. This review addresses the various aspects of surgery-induced metastasis formation and sheds light on the role of inflammation as potential trigger for metastasis development. Understanding these mechanisms may provide potential new perioperative interventions to improve treatment outcomes, and as such could transform the perioperative timeframe from a facilitator of metastatic progression to a window of opportunity to reduce the risk of liver metastasis development. Ultimately, this can potentially improve long-term survival rates and quality of life in patients with colorectal cancer. |
| first_indexed | 2024-03-09T04:45:10Z |
| format | Article |
| id | doaj.art-9daceec3e1fd488eb8f55c6a3d7bc91d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T04:45:10Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-9daceec3e1fd488eb8f55c6a3d7bc91d2023-12-03T13:17:05ZengMDPI AGBiomedicines2227-90592021-02-019217710.3390/biomedicines9020177Surgery for Colorectal Cancer: A Trigger for Liver Metastases Development? New Insights into the Underlying MechanismsSimran Grewal0Steven J. Oosterling1Marjolein van Egmond2Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Centers, 1007 MB Amsterdam, The NetherlandsDepartment of Surgery, Spaarne Gasthuis, 2035 RC Haarlem, The NetherlandsDepartment of Molecular Cell Biology and Immunology, Amsterdam University Medical Centers, 1007 MB Amsterdam, The NetherlandsSurgery is a crucial intervention and provides the best chance of cure for patients with colorectal cancer. Experimental and clinical evidence, however, suggests that paradoxically surgery itself may precipitate or accelerate tumor recurrence and/or liver metastasis development. This review addresses the various aspects of surgery-induced metastasis formation and sheds light on the role of inflammation as potential trigger for metastasis development. Understanding these mechanisms may provide potential new perioperative interventions to improve treatment outcomes, and as such could transform the perioperative timeframe from a facilitator of metastatic progression to a window of opportunity to reduce the risk of liver metastasis development. Ultimately, this can potentially improve long-term survival rates and quality of life in patients with colorectal cancer.https://www.mdpi.com/2227-9059/9/2/177colorectal cancerimmunologyliver metastasestreatment |
| spellingShingle | Simran Grewal Steven J. Oosterling Marjolein van Egmond Surgery for Colorectal Cancer: A Trigger for Liver Metastases Development? New Insights into the Underlying Mechanisms Biomedicines colorectal cancer immunology liver metastases treatment |
| title | Surgery for Colorectal Cancer: A Trigger for Liver Metastases Development? New Insights into the Underlying Mechanisms |
| title_full | Surgery for Colorectal Cancer: A Trigger for Liver Metastases Development? New Insights into the Underlying Mechanisms |
| title_fullStr | Surgery for Colorectal Cancer: A Trigger for Liver Metastases Development? New Insights into the Underlying Mechanisms |
| title_full_unstemmed | Surgery for Colorectal Cancer: A Trigger for Liver Metastases Development? New Insights into the Underlying Mechanisms |
| title_short | Surgery for Colorectal Cancer: A Trigger for Liver Metastases Development? New Insights into the Underlying Mechanisms |
| title_sort | surgery for colorectal cancer a trigger for liver metastases development new insights into the underlying mechanisms |
| topic | colorectal cancer immunology liver metastases treatment |
| url | https://www.mdpi.com/2227-9059/9/2/177 |
| work_keys_str_mv | AT simrangrewal surgeryforcolorectalcanceratriggerforlivermetastasesdevelopmentnewinsightsintotheunderlyingmechanisms AT stevenjoosterling surgeryforcolorectalcanceratriggerforlivermetastasesdevelopmentnewinsightsintotheunderlyingmechanisms AT marjoleinvanegmond surgeryforcolorectalcanceratriggerforlivermetastasesdevelopmentnewinsightsintotheunderlyingmechanisms |