A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson’s disease model
As a neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP)-preferring receptor, PAC1-R mediates effective neuroprotective activity. Based on the finding that the antibiotic doxycycline (DOX) with clinical neuroprotective activity functions as a positive allosteric modulator (PAM) o...
Main Authors: | Fan Guangchun, Chen Shang, Tao Zhengxin, Zhang Huahua, Yu Rongjie |
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Format: | Article |
Language: | English |
Published: |
China Science Publishing & Media Ltd.
2022-09-01
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Series: | Acta Biochimica et Biophysica Sinica |
Subjects: | |
Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2022126 |
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