A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson’s disease model

A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson’s disease model

As a neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP)-preferring receptor, PAC1-R mediates effective neuroprotective activity. Based on the finding that the antibiotic doxycycline (DOX) with clinical neuroprotective activity functions as a positive allosteric modulator (PAM) o...

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Bibliographic Details
Main Authors: Fan Guangchun, Chen Shang, Tao Zhengxin, Zhang Huahua, Yu Rongjie
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-09-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
positive allosteric modulator
PACAP receptor 1
doxycycline
computer virtual screening
neuroprotective activity
Parkinson’s disease
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022126

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