Block of Voltage-Gated Sodium Channels by Aripiprazole in a State-Dependent Manner

Block of Voltage-Gated Sodium Channels by Aripiprazole in a State-Dependent Manner

Aripiprazole is an atypical antipsychotic drug, which is prescribed for many psychiatric diseases such as schizophrenia and mania in bipolar disorder. It primarily acts as an agonist of dopaminergic and other G-protein coupled receptors. So far, an interaction with ligand- or voltage-gated ion chann...

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Bibliographic Details
Main Authors: Karl Josef Föhr, Michael Rapp, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, David Alexander Christian Messerer
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
aripiprazole
sodium channel
cardiotoxicity
electrophysiology
patch clamp
Online Access:https://www.mdpi.com/1422-0067/23/21/12890

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