Evaluation of oxidative stress and thyroid hormone status in hemodialysis patients in Gorgan
Aims: The aim of this study focused on serum malondialdehyde (MDA) levels and erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities in hemodialysis patients and compared with control groups. Materials and Methods: Forty-five hemodialyzed patients and 45 control groups recruited in thi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=3;spage=348;epage=353;aulast=Velayeti |
| _version_ | 1818300734729355264 |
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| author | Javad Velayeti Azad Reza Mansourian Mohammad Mojerloo Abdoljalal Marjani |
| author_facet | Javad Velayeti Azad Reza Mansourian Mohammad Mojerloo Abdoljalal Marjani |
| author_sort | Javad Velayeti |
| collection | DOAJ |
| description | Aims: The aim of this study focused on serum malondialdehyde (MDA) levels and erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities in hemodialysis patients and compared with control groups. Materials and Methods: Forty-five hemodialyzed patients and 45 control groups recruited in this study. Serum creatinine and urea, thyroid hormones (THs) levels and erythrocyte antioxidant enzyme activities were determined. Results: Hemodialysis (HD) patients showed higher levels of MDA than control groups (P < 0.01), but the levels of thyroxin (T3), free triiodothyronine (fT3), and free thyroxin (fT4), SOD and CAT were low in HD patients (P < 0.01). Serum T3, fT3, and fT4 levels were significantly negative correlated with MDA (P < 0.01). Conclusion: It is concluded that serum lipid peroxidation is markedly increased in HD patients. This means that elevated reactive oxygen species may interact with the lipid molecules in HD patients. HD may cause significant changes in TH levels. Thyroid-stimulating hormone level in HD patients is slightly similar to that of control groups. This suggests that thyroid is able to resynthesize for hormonal urinary losses. |
| first_indexed | 2024-12-13T05:11:50Z |
| format | Article |
| id | doaj.art-9daf5620373d46adbd53a6bdc1209a3d |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-12-13T05:11:50Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-9daf5620373d46adbd53a6bdc1209a3d2022-12-21T23:58:31ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002016-01-0120334835310.4103/2230-8210.179986Evaluation of oxidative stress and thyroid hormone status in hemodialysis patients in GorganJavad VelayetiAzad Reza MansourianMohammad MojerlooAbdoljalal MarjaniAims: The aim of this study focused on serum malondialdehyde (MDA) levels and erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities in hemodialysis patients and compared with control groups. Materials and Methods: Forty-five hemodialyzed patients and 45 control groups recruited in this study. Serum creatinine and urea, thyroid hormones (THs) levels and erythrocyte antioxidant enzyme activities were determined. Results: Hemodialysis (HD) patients showed higher levels of MDA than control groups (P < 0.01), but the levels of thyroxin (T3), free triiodothyronine (fT3), and free thyroxin (fT4), SOD and CAT were low in HD patients (P < 0.01). Serum T3, fT3, and fT4 levels were significantly negative correlated with MDA (P < 0.01). Conclusion: It is concluded that serum lipid peroxidation is markedly increased in HD patients. This means that elevated reactive oxygen species may interact with the lipid molecules in HD patients. HD may cause significant changes in TH levels. Thyroid-stimulating hormone level in HD patients is slightly similar to that of control groups. This suggests that thyroid is able to resynthesize for hormonal urinary losses.http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=3;spage=348;epage=353;aulast=VelayetiAntioxidant enzymeshemodialysislipid peroxidationthyroid hormones |
| spellingShingle | Javad Velayeti Azad Reza Mansourian Mohammad Mojerloo Abdoljalal Marjani Evaluation of oxidative stress and thyroid hormone status in hemodialysis patients in Gorgan Indian Journal of Endocrinology and Metabolism Antioxidant enzymes hemodialysis lipid peroxidation thyroid hormones |
| title | Evaluation of oxidative stress and thyroid hormone status in hemodialysis patients in Gorgan |
| title_full | Evaluation of oxidative stress and thyroid hormone status in hemodialysis patients in Gorgan |
| title_fullStr | Evaluation of oxidative stress and thyroid hormone status in hemodialysis patients in Gorgan |
| title_full_unstemmed | Evaluation of oxidative stress and thyroid hormone status in hemodialysis patients in Gorgan |
| title_short | Evaluation of oxidative stress and thyroid hormone status in hemodialysis patients in Gorgan |
| title_sort | evaluation of oxidative stress and thyroid hormone status in hemodialysis patients in gorgan |
| topic | Antioxidant enzymes hemodialysis lipid peroxidation thyroid hormones |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=3;spage=348;epage=353;aulast=Velayeti |
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