Synthesis and Biological Evaluation of New Dihydrofuro[3,2-<i>b</i>]piperidine Derivatives as Potent <i>α</i>-Glucosidase Inhibitors

Synthesis and Biological Evaluation of New Dihydrofuro[3,2-<i>b</i>]piperidine Derivatives as Potent <i>α</i>-Glucosidase Inhibitors

Inhibition of glycoside hydrolases has widespread application in the treatment of diabetes. Based on our previous findings, a series of dihydrofuro[3,2-<i>b</i>]piperidine derivatives was designed and synthesized from D- and L-arabinose. Compounds <b>32</b> (IC<sub>50&l...

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Bibliographic Details
Main Authors: Haibo Wang, Xiaojiang Huang, Yang Pan, Guoqing Zhang, Senling Tang, Huawu Shao, Wei Jiao
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
dihydrofuro[3,2-<i>b</i>]piperidine
iminosugar
<i>C</i>-glycosides
glucosidase
inhibitors
Online Access:https://www.mdpi.com/1420-3049/29/5/1179
Description
Summary:Inhibition of glycoside hydrolases has widespread application in the treatment of diabetes. Based on our previous findings, a series of dihydrofuro[3,2-<i>b</i>]piperidine derivatives was designed and synthesized from D- and L-arabinose. Compounds <b>32</b> (IC<sub>50</sub> = 0.07 μM) and <b>28</b> (IC<sub>50</sub> = 0.5 μM) showed significantly stronger inhibitory potency against <i>α</i>-glucosidase than positive control acarbose. The study of the structure–activity relationship of these compounds provides a new clue for the development of new <i>α</i>-glucosidase inhibitors.
ISSN:1420-3049

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