Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials

Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials

Abstract Background The clinical utility of serum procalcitonin levels in guiding antibiotic treatment decisions in patients with sepsis remains unclear. This patient-level meta-analysis based on 11 randomized trials investigates the impact of procalcitonin-guided antibiotic therapy on mortality in...

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Bibliographic Details
Main Authors: Yannick Wirz, Marc A. Meier, Lila Bouadma, Charles E. Luyt, Michel Wolff, Jean Chastre, Florence Tubach, Stefan Schroeder, Vandack Nobre, Djillali Annane, Konrad Reinhart, Pierre Damas, Maarten Nijsten, Arezoo Shajiei, Dylan W. deLange, Rodrigo O. Deliberato, Carolina F. Oliveira, Yahya Shehabi, Jos A. H. van Oers, Albertus Beishuizen, Armand R. J. Girbes, Evelien de Jong, Beat Mueller, Philipp Schuetz
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Critical Care
Subjects:
Sepsis
Procalcitonin
Antibiotic stewardship
Meta-analysis
Online Access:http://link.springer.com/article/10.1186/s13054-018-2125-7

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