Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity
Abstract Cancer immunotherapy has become a mainstream cancer treatment over traditional therapeutic modes. Cancer cells can undergo programmed cell death including ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis which are find to have intrinsic relationships with host anti...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202306580 |
| _version_ | 1797351443956498432 |
|---|---|
| author | Yongjuan Li Yichen Guo Kaixin Zhang Rongrong Zhu Xiaoyuan Chen Zhenzhong Zhang Weijing Yang |
| author_facet | Yongjuan Li Yichen Guo Kaixin Zhang Rongrong Zhu Xiaoyuan Chen Zhenzhong Zhang Weijing Yang |
| author_sort | Yongjuan Li |
| collection | DOAJ |
| description | Abstract Cancer immunotherapy has become a mainstream cancer treatment over traditional therapeutic modes. Cancer cells can undergo programmed cell death including ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis which are find to have intrinsic relationships with host antitumor immune response. However, direct use of cell death inducers or regulators may bring about severe side effects that can also be rapidly excreted and degraded with low therapeutic efficacy. Nanomaterials are able to carry them for long circulation time, high tumor accumulation and controlled release to achieve satisfactory therapeutic effect. Nowadays, a large number of studies have focused on nanomedicines‐based strategies through modulating cell death modalities to potentiate antitumor immunity. Herein, immune cell types and their function are first summarized, and state‐of‐the‐art research progresses in nanomedicines mediated cell death pathways (e.g., ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis) with immune response provocation are highlighted. Subsequently, the conclusion and outlook of potential research focus are discussed. |
| first_indexed | 2024-03-08T13:00:31Z |
| format | Article |
| id | doaj.art-9db26378869b427c88dc53e64225ef51 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-08T13:00:31Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-9db26378869b427c88dc53e64225ef512024-01-19T09:27:54ZengWileyAdvanced Science2198-38442024-01-01113n/an/a10.1002/advs.202306580Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor ImmunityYongjuan Li0Yichen Guo1Kaixin Zhang2Rongrong Zhu3Xiaoyuan Chen4Zhenzhong Zhang5Weijing Yang6School of Pharmaceutical Sciences Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou University Zhengzhou Henan 450001 ChinaSchool of Pharmaceutical Sciences Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou University Zhengzhou Henan 450001 ChinaSchool of Pharmaceutical Sciences Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou University Zhengzhou Henan 450001 ChinaSchool of Pharmaceutical Sciences Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou University Zhengzhou Henan 450001 ChinaDepartments of Diagnostic Radiology, Surgery Chemical and Biomolecular Engineering, and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119074 SingaporeSchool of Pharmaceutical Sciences Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou University Zhengzhou Henan 450001 ChinaSchool of Pharmaceutical Sciences Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou University Zhengzhou Henan 450001 ChinaAbstract Cancer immunotherapy has become a mainstream cancer treatment over traditional therapeutic modes. Cancer cells can undergo programmed cell death including ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis which are find to have intrinsic relationships with host antitumor immune response. However, direct use of cell death inducers or regulators may bring about severe side effects that can also be rapidly excreted and degraded with low therapeutic efficacy. Nanomaterials are able to carry them for long circulation time, high tumor accumulation and controlled release to achieve satisfactory therapeutic effect. Nowadays, a large number of studies have focused on nanomedicines‐based strategies through modulating cell death modalities to potentiate antitumor immunity. Herein, immune cell types and their function are first summarized, and state‐of‐the‐art research progresses in nanomedicines mediated cell death pathways (e.g., ferroptosis, pyroptosis, autophagy, necroptosis, apoptosis and cuproptosis) with immune response provocation are highlighted. Subsequently, the conclusion and outlook of potential research focus are discussed.https://doi.org/10.1002/advs.202306580apoptosis and cuproptosisautophagy and necroptosiscancer immunotherapyferroptosis and pyroptosisnanomedicines |
| spellingShingle | Yongjuan Li Yichen Guo Kaixin Zhang Rongrong Zhu Xiaoyuan Chen Zhenzhong Zhang Weijing Yang Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity Advanced Science apoptosis and cuproptosis autophagy and necroptosis cancer immunotherapy ferroptosis and pyroptosis nanomedicines |
| title | Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity |
| title_full | Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity |
| title_fullStr | Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity |
| title_full_unstemmed | Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity |
| title_short | Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity |
| title_sort | cell death pathway regulation by functional nanomedicines for robust antitumor immunity |
| topic | apoptosis and cuproptosis autophagy and necroptosis cancer immunotherapy ferroptosis and pyroptosis nanomedicines |
| url | https://doi.org/10.1002/advs.202306580 |
| work_keys_str_mv | AT yongjuanli celldeathpathwayregulationbyfunctionalnanomedicinesforrobustantitumorimmunity AT yichenguo celldeathpathwayregulationbyfunctionalnanomedicinesforrobustantitumorimmunity AT kaixinzhang celldeathpathwayregulationbyfunctionalnanomedicinesforrobustantitumorimmunity AT rongrongzhu celldeathpathwayregulationbyfunctionalnanomedicinesforrobustantitumorimmunity AT xiaoyuanchen celldeathpathwayregulationbyfunctionalnanomedicinesforrobustantitumorimmunity AT zhenzhongzhang celldeathpathwayregulationbyfunctionalnanomedicinesforrobustantitumorimmunity AT weijingyang celldeathpathwayregulationbyfunctionalnanomedicinesforrobustantitumorimmunity |