An examination of the reliability of seed-to-seed resting state functional connectivity in tinnitus patients
Resting state functional connectivity (RS-FC) studies of tinnitus over the years have produced inconsistent results. While findings can be organized into broad categories, such as increased correlations between auditory and limbic areas in tinnitus patients and a disrupted default mode network, ther...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Neuroimage: Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266695602300003X |
| _version_ | 1827989989240078336 |
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| author | Sara A. Schmidt Somayeh Shahsavarani Rafay A. Khan Yihsin Tai Elsa C. Granato Caterina M. Willson Pedro Ramos Paul Sherman Carlos Esquivel Bradley P. Sutton Fatima T. Husain |
| author_facet | Sara A. Schmidt Somayeh Shahsavarani Rafay A. Khan Yihsin Tai Elsa C. Granato Caterina M. Willson Pedro Ramos Paul Sherman Carlos Esquivel Bradley P. Sutton Fatima T. Husain |
| author_sort | Sara A. Schmidt |
| collection | DOAJ |
| description | Resting state functional connectivity (RS-FC) studies of tinnitus over the years have produced inconsistent results. While findings can be organized into broad categories, such as increased correlations between auditory and limbic areas in tinnitus patients and a disrupted default mode network, there has been little one-to-one correspondence of results across RS-FC studies of tinnitus. While some of this variation can be explained by the heterogeneity of the tinnitus population, including tinnitus severity, the sources of variability in RS-FC of tinnitus patients are unclear. To directly assess the reliability of RS-FC measures in tinnitus, both tinnitus and control participants from two different sites (University of Illinois at Urbana-Champaign, or UIUC, and the Wilford Hall Ambulatory Surgical Center, or WHASC, at the Lackland Airforce Base in San Antonio, Texas) participated in two resting state MRI scans separated by exactly one week. Seed-to-seed analysis assessing correlations between the fMRI activity of 27 regions in the default mode, dorsal attention, auditory, visual, salience, and emotional processing networks were examined in control and tinnitus participants separately for each site. Additionally, heart rate and respiration measures were collected at UIUC, and the effect of extra physiological corrections using these measures on reliability was examined within the UIUC participants. Intra-class correlation coefficients (ICCs) were used as the measure of reliability. Overall, RS-FC in a seed-to-seed analysis was as reliable in tinnitus participants as it was in control participants in the seed regions examined. As previously shown in studies of participants with normal hearing sensitivity, intra-network reliability was higher than inter-network reliability. Related to this, stronger correlations between two seed regions were predictive of stronger reliability of the connectivity between those regions. These effects were seen in both control and tinnitus populations. Additional physiological corrections did not have a significant impact on the ICC values. The current study demonstrates that, on a whole-brain level, RS-FC assessed via seed-to-seed analysis is reliable in tinnitus participants. We therefore must look to other sources as potential causes of discrepancies across studies, such as variability within analysis techniques or within the behavioral characteristics of tinnitus participants. |
| first_indexed | 2024-04-10T00:30:03Z |
| format | Article |
| id | doaj.art-9db5cfe6de544e6fa344eea3d8bf594a |
| institution | Directory Open Access Journal |
| issn | 2666-9560 |
| language | English |
| last_indexed | 2024-04-10T00:30:03Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroimage: Reports |
| spelling | doaj.art-9db5cfe6de544e6fa344eea3d8bf594a2023-03-15T04:29:12ZengElsevierNeuroimage: Reports2666-95602023-03-0131100158An examination of the reliability of seed-to-seed resting state functional connectivity in tinnitus patientsSara A. Schmidt0Somayeh Shahsavarani1Rafay A. Khan2Yihsin Tai3Elsa C. Granato4Caterina M. Willson5Pedro Ramos6Paul Sherman7Carlos Esquivel8Bradley P. Sutton9Fatima T. Husain10The Neuroscience Program, University of Illinois at Urbana-Champaign, USA; Beckman Institute for Advance Science and Technology, University of Illinois at Urbana-Champaign, USAMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, USAThe Neuroscience Program, University of Illinois at Urbana-Champaign, USA; Beckman Institute for Advance Science and Technology, University of Illinois at Urbana-Champaign, USADepartment of Speech Pathology and Audiology, Ball State University, USADepartment of Defense Hearing Center of Excellence, San Antonio, TX, USA; zCore Business Solutions, Inc., Round Rock, TX, USADepartment of Defense Hearing Center of Excellence, San Antonio, TX, USA; The Geneva Foundation, Tacoma, WA, USADecypher Technologies, San Antonio, TX, USA; 711th Human Performance Wing (HPW), USAF School of Aerospace Medicine, Wright Patterson AFB, OH, USA711th Human Performance Wing (HPW), USAF School of Aerospace Medicine, Wright Patterson AFB, OH, USA; 59th Medical Wing, Department of Radiology, Joint Base San Antonio, TX, USADepartment of Defense Hearing Center of Excellence, San Antonio, TX, USAThe Neuroscience Program, University of Illinois at Urbana-Champaign, USA; Beckman Institute for Advance Science and Technology, University of Illinois at Urbana-Champaign, USA; Department of Bioengineering, University of Illinois at Urbana-Champaign, USA; Biomedical Imaging Center, University of Illinois at Urbana-Champaign, USAThe Neuroscience Program, University of Illinois at Urbana-Champaign, USA; Beckman Institute for Advance Science and Technology, University of Illinois at Urbana-Champaign, USA; Department of Speech and Hearing Science, University of Illinois at Urbana-Champaign, USA; Corresponding author. 901 S Sixth Street, Champaign, IL, 61820, USA.Resting state functional connectivity (RS-FC) studies of tinnitus over the years have produced inconsistent results. While findings can be organized into broad categories, such as increased correlations between auditory and limbic areas in tinnitus patients and a disrupted default mode network, there has been little one-to-one correspondence of results across RS-FC studies of tinnitus. While some of this variation can be explained by the heterogeneity of the tinnitus population, including tinnitus severity, the sources of variability in RS-FC of tinnitus patients are unclear. To directly assess the reliability of RS-FC measures in tinnitus, both tinnitus and control participants from two different sites (University of Illinois at Urbana-Champaign, or UIUC, and the Wilford Hall Ambulatory Surgical Center, or WHASC, at the Lackland Airforce Base in San Antonio, Texas) participated in two resting state MRI scans separated by exactly one week. Seed-to-seed analysis assessing correlations between the fMRI activity of 27 regions in the default mode, dorsal attention, auditory, visual, salience, and emotional processing networks were examined in control and tinnitus participants separately for each site. Additionally, heart rate and respiration measures were collected at UIUC, and the effect of extra physiological corrections using these measures on reliability was examined within the UIUC participants. Intra-class correlation coefficients (ICCs) were used as the measure of reliability. Overall, RS-FC in a seed-to-seed analysis was as reliable in tinnitus participants as it was in control participants in the seed regions examined. As previously shown in studies of participants with normal hearing sensitivity, intra-network reliability was higher than inter-network reliability. Related to this, stronger correlations between two seed regions were predictive of stronger reliability of the connectivity between those regions. These effects were seen in both control and tinnitus populations. Additional physiological corrections did not have a significant impact on the ICC values. The current study demonstrates that, on a whole-brain level, RS-FC assessed via seed-to-seed analysis is reliable in tinnitus participants. We therefore must look to other sources as potential causes of discrepancies across studies, such as variability within analysis techniques or within the behavioral characteristics of tinnitus participants.http://www.sciencedirect.com/science/article/pii/S266695602300003XTinnitusResting state functional connectivityfMRIReliabilityICCDefault mode network |
| spellingShingle | Sara A. Schmidt Somayeh Shahsavarani Rafay A. Khan Yihsin Tai Elsa C. Granato Caterina M. Willson Pedro Ramos Paul Sherman Carlos Esquivel Bradley P. Sutton Fatima T. Husain An examination of the reliability of seed-to-seed resting state functional connectivity in tinnitus patients Neuroimage: Reports Tinnitus Resting state functional connectivity fMRI Reliability ICC Default mode network |
| title | An examination of the reliability of seed-to-seed resting state functional connectivity in tinnitus patients |
| title_full | An examination of the reliability of seed-to-seed resting state functional connectivity in tinnitus patients |
| title_fullStr | An examination of the reliability of seed-to-seed resting state functional connectivity in tinnitus patients |
| title_full_unstemmed | An examination of the reliability of seed-to-seed resting state functional connectivity in tinnitus patients |
| title_short | An examination of the reliability of seed-to-seed resting state functional connectivity in tinnitus patients |
| title_sort | examination of the reliability of seed to seed resting state functional connectivity in tinnitus patients |
| topic | Tinnitus Resting state functional connectivity fMRI Reliability ICC Default mode network |
| url | http://www.sciencedirect.com/science/article/pii/S266695602300003X |
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