Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation—Post-Hoc Analysis of the J-MINUET Study
Background: A Japanese prospective, nation-wide, multicenter registry (J-MINUET) showed that long-term outcomes were worse in non-ST elevation acute myocardial infarction (NSTEMI), diagnosed by increased cardiac troponin levels, compared to STEMI. This was observed in both non-STEMI with elevated cr...
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MDPI AG
2020-08-01
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| author | Shigeru Toyoda Masashi Sakuma Shichiro Abe Teruo Inoue Koichi Nakao Yukio Ozaki Kazuo Kimura Junya Ako Teruo Noguchi Satoru Suwa Kazuteru Fujimoto Yasuharu Nakama Takashi Morita Wataru Shimizu Yoshihiko Saito Atsushi Hirohata Yasuhiro Morita Atsunori Okamura Toshiaki Mano Minoru Wake Kengo Tanabe Yoshisato Shibata Mafumi Owa Kenichi Tsujita Hiroshi Funayama Nobuaki Kokubu Ken Kozuma Tetsuya Toubaru Keijirou Saku Shigeru Ohshima Yoshihiro Miyamoto Hisao Ogawa Masaharu Ishihara |
| author_facet | Shigeru Toyoda Masashi Sakuma Shichiro Abe Teruo Inoue Koichi Nakao Yukio Ozaki Kazuo Kimura Junya Ako Teruo Noguchi Satoru Suwa Kazuteru Fujimoto Yasuharu Nakama Takashi Morita Wataru Shimizu Yoshihiko Saito Atsushi Hirohata Yasuhiro Morita Atsunori Okamura Toshiaki Mano Minoru Wake Kengo Tanabe Yoshisato Shibata Mafumi Owa Kenichi Tsujita Hiroshi Funayama Nobuaki Kokubu Ken Kozuma Tetsuya Toubaru Keijirou Saku Shigeru Ohshima Yoshihiro Miyamoto Hisao Ogawa Masaharu Ishihara |
| author_sort | Shigeru Toyoda |
| collection | DOAJ |
| description | Background: A Japanese prospective, nation-wide, multicenter registry (J-MINUET) showed that long-term outcomes were worse in non-ST elevation acute myocardial infarction (NSTEMI), diagnosed by increased cardiac troponin levels, compared to STEMI. This was observed in both non-STEMI with elevated creatine kinase (CK) (NSTEMI+CK) and non-STEMI without elevated CK (NSTEMI-CK). However, predictive factors for long-term outcomes in STEMI, NSTEMI+CK, and NSTEMI-CK have not been elucidated. Methods: Using the Cox proportional hazards model, we determined significant independent predictors of long-term outcomes from a total of 111 parameters evaluated in the J-MINUET study in each of our groups, including STEMI, NSTEMI+CK, and NSTEMI-CK. Then, we calculated the risk score using the regression coefficients for the determined independent predictors for the strict prediction of long-term outcomes. Results: Prognostic factors, as well as composite cardiovascular events and all-cause death, were different between STEMI, NSTEMI+CK, and NSTEMI-CK. Risk scores could effectively and powerfully predict both composite cardiovascular events and all-cause death in each group. Conclusions: The prediction of long-term outcomes using cored parameters of baseline demographics and clinical characteristics is feasible and could prove useful in establishing therapeutic strategies in patients with STEMI, NSTEMI+CK, and NSTEMI-CK. |
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| last_indexed | 2024-03-10T17:16:27Z |
| publishDate | 2020-08-01 |
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| spelling | doaj.art-9db88998d43543bf90df828357d9c9d42023-11-20T10:29:59ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0198266710.3390/jcm9082667Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation—Post-Hoc Analysis of the J-MINUET StudyShigeru Toyoda0Masashi Sakuma1Shichiro Abe2Teruo Inoue3Koichi Nakao4Yukio Ozaki5Kazuo Kimura6Junya Ako7Teruo Noguchi8Satoru Suwa9Kazuteru Fujimoto10Yasuharu Nakama11Takashi Morita12Wataru Shimizu13Yoshihiko Saito14Atsushi Hirohata15Yasuhiro Morita16Atsunori Okamura17Toshiaki Mano18Minoru Wake19Kengo Tanabe20Yoshisato Shibata21Mafumi Owa22Kenichi Tsujita23Hiroshi Funayama24Nobuaki Kokubu25Ken Kozuma26Tetsuya Toubaru27Keijirou Saku28Shigeru Ohshima29Yoshihiro Miyamoto30Hisao Ogawa31Masaharu Ishihara32Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu 321-0293, JapanDepartment of Cardiovascular Medicine, Dokkyo Medical University, Mibu 321-0293, JapanDepartment of Cardiovascular Medicine, Dokkyo Medical University, Mibu 321-0293, JapanDepartment of Cardiovascular Medicine, Dokkyo Medical University, Mibu 321-0293, JapanDivision of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto 861-4193, JapanDepartment of Cardiology, Fujita Health University, Toyoake 470-1101, JapanCardiovascular Center, Yokohama City University Medical Center, Yokohama 236-0004, JapanDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara 252-0375, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita 565-8565, JapanDepartment of Cardiology, Juntendo University Shizuoka Hospital, Izunokuni 410-2295, JapanDepartment of Cardiology, National Hospital Organization Kumamoto Medical Center, Kumamoto 860-0088, JapanDepartment of Cardiology, Hiroshima City Hospital, Hiroshima 730-8518, JapanDivision of Cardiology, Osaka General Medical Center, Osaka 558-8558, JapanDepartment of Cardiovascular Medicine, Nippon Medical School, Tokyo 113-8603, JapanFirst Department of Internal Medicine, Nara Medical University, Kashihara 634-8521, JapanDepartment of Cardiovascular Medicine, The Sakakibara Heart Institute of Okayama, Okayama 700-0804, JapanDepartment of Cardiology, Ogaki Municipal Hospital, Ogaki 503-8502, JapanDepartment of Cardiology, Sakurabashi Watanabe Hospital, Osaka 530-0001, JapanInstitute for Clinical Research, Kansai Rosai Hospital, Osaka 660-8511, JapanDepartment of Cardiology, Okinawa Chubu Hospital, Uruma 904-2293, JapanDivision of Cardiology, Mitsui Memorial Hospital, Tokyo 101-8043, JapanDepartment of Cardiology, Miyazaki Medical Association Hospital, Miyazaki 880-0834, JapanDepartment of Cardiovascular Medicine, Suwa Red Cross Hospital, Suwa 392-8510, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, JapanDivision of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi 329-0498, JapanDepartment of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University, Sapporo 060-8543, JapanDepartment of Cardiology, Teikyo University, Tokyo 173-8606, JapanDepartment of Cardiology, Sakakibara Heart Institute, Tokyo 183-0003, JapanDepartment of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0133, JapanDepartment of Cardiology, Gunma Prefectural Cardiovascular Center, Maebashi 371-0004, JapanDepartment of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita 565-8565, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita 565-8565, JapanDepartment of Cardiovascular and Renal Medicine, Hyogo College of Medicine, Nishinomiya 663-8501, JapanBackground: A Japanese prospective, nation-wide, multicenter registry (J-MINUET) showed that long-term outcomes were worse in non-ST elevation acute myocardial infarction (NSTEMI), diagnosed by increased cardiac troponin levels, compared to STEMI. This was observed in both non-STEMI with elevated creatine kinase (CK) (NSTEMI+CK) and non-STEMI without elevated CK (NSTEMI-CK). However, predictive factors for long-term outcomes in STEMI, NSTEMI+CK, and NSTEMI-CK have not been elucidated. Methods: Using the Cox proportional hazards model, we determined significant independent predictors of long-term outcomes from a total of 111 parameters evaluated in the J-MINUET study in each of our groups, including STEMI, NSTEMI+CK, and NSTEMI-CK. Then, we calculated the risk score using the regression coefficients for the determined independent predictors for the strict prediction of long-term outcomes. Results: Prognostic factors, as well as composite cardiovascular events and all-cause death, were different between STEMI, NSTEMI+CK, and NSTEMI-CK. Risk scores could effectively and powerfully predict both composite cardiovascular events and all-cause death in each group. Conclusions: The prediction of long-term outcomes using cored parameters of baseline demographics and clinical characteristics is feasible and could prove useful in establishing therapeutic strategies in patients with STEMI, NSTEMI+CK, and NSTEMI-CK.https://www.mdpi.com/2077-0383/9/8/2667myocardial infarctioncardiac troponincreatine kinasepredictor of prognosisrisk score |
| spellingShingle | Shigeru Toyoda Masashi Sakuma Shichiro Abe Teruo Inoue Koichi Nakao Yukio Ozaki Kazuo Kimura Junya Ako Teruo Noguchi Satoru Suwa Kazuteru Fujimoto Yasuharu Nakama Takashi Morita Wataru Shimizu Yoshihiko Saito Atsushi Hirohata Yasuhiro Morita Atsunori Okamura Toshiaki Mano Minoru Wake Kengo Tanabe Yoshisato Shibata Mafumi Owa Kenichi Tsujita Hiroshi Funayama Nobuaki Kokubu Ken Kozuma Tetsuya Toubaru Keijirou Saku Shigeru Ohshima Yoshihiro Miyamoto Hisao Ogawa Masaharu Ishihara Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation—Post-Hoc Analysis of the J-MINUET Study Journal of Clinical Medicine myocardial infarction cardiac troponin creatine kinase predictor of prognosis risk score |
| title | Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation—Post-Hoc Analysis of the J-MINUET Study |
| title_full | Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation—Post-Hoc Analysis of the J-MINUET Study |
| title_fullStr | Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation—Post-Hoc Analysis of the J-MINUET Study |
| title_full_unstemmed | Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation—Post-Hoc Analysis of the J-MINUET Study |
| title_short | Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation—Post-Hoc Analysis of the J-MINUET Study |
| title_sort | prediction of long term outcomes in st elevation myocardial infarction and non st elevation myocardial infarction with and without creatinine kinase elevation post hoc analysis of the j minuet study |
| topic | myocardial infarction cardiac troponin creatine kinase predictor of prognosis risk score |
| url | https://www.mdpi.com/2077-0383/9/8/2667 |
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