Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of <i>Aspergillus</i> and <i>Penicillium</i> Genera
Low molecular weight secondary metabolites of marine fungi <i>Aspergillus flocculosus</i>, <i>Aspergillus terreus</i> and <i>Penicillium</i> sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoid...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/18/12/608 |
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| author | Elena V. Girich Anton N. Yurchenko Olga F. Smetanina Phan Thi Hoai Trinh Ngo Thi Duy Ngoc Mikhail V. Pivkin Roman S. Popov Evgeny A. Pislyagin Ekaterina S. Menchinskaya Ekaterina A. Chingizova Shamil S. Afiyatullov Ekaterina A. Yurchenko |
| author_facet | Elena V. Girich Anton N. Yurchenko Olga F. Smetanina Phan Thi Hoai Trinh Ngo Thi Duy Ngoc Mikhail V. Pivkin Roman S. Popov Evgeny A. Pislyagin Ekaterina S. Menchinskaya Ekaterina A. Chingizova Shamil S. Afiyatullov Ekaterina A. Yurchenko |
| author_sort | Elena V. Girich |
| collection | DOAJ |
| description | Low molecular weight secondary metabolites of marine fungi <i>Aspergillus flocculosus</i>, <i>Aspergillus terreus</i> and <i>Penicillium</i> sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F (<b>6</b>) was thoroughly described for the first time. Anthraquinone (<b>13</b>) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (<b>1</b>), 4-hydroxy-6-dehydroxyscytalone (<b>2</b>) and demethylcitreoviranol (<b>3</b>) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity. |
| first_indexed | 2024-03-10T14:26:24Z |
| format | Article |
| id | doaj.art-9dba6e406c404778971acf5e6b137c69 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T14:26:24Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-9dba6e406c404778971acf5e6b137c692023-11-20T22:56:51ZengMDPI AGMarine Drugs1660-33972020-11-01181260810.3390/md18120608Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of <i>Aspergillus</i> and <i>Penicillium</i> GeneraElena V. Girich0Anton N. Yurchenko1Olga F. Smetanina2Phan Thi Hoai Trinh3Ngo Thi Duy Ngoc4Mikhail V. Pivkin5Roman S. Popov6Evgeny A. Pislyagin7Ekaterina S. Menchinskaya8Ekaterina A. Chingizova9Shamil S. Afiyatullov10Ekaterina A. Yurchenko11G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, RussiaDepartment of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, VietnamDepartment of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang 650000, VietnamG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 690950 Vladivostok, RussiaLow molecular weight secondary metabolites of marine fungi <i>Aspergillus flocculosus</i>, <i>Aspergillus terreus</i> and <i>Penicillium</i> sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F (<b>6</b>) was thoroughly described for the first time. Anthraquinone (<b>13</b>) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (<b>1</b>), 4-hydroxy-6-dehydroxyscytalone (<b>2</b>) and demethylcitreoviranol (<b>3</b>) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.https://www.mdpi.com/1660-3397/18/12/608<i>Aspergillus terreus</i><i>Aspergillus flocculosus</i><i>Penicillium</i> sp.marine-derived fungiSouth China Seasecondary metabolites |
| spellingShingle | Elena V. Girich Anton N. Yurchenko Olga F. Smetanina Phan Thi Hoai Trinh Ngo Thi Duy Ngoc Mikhail V. Pivkin Roman S. Popov Evgeny A. Pislyagin Ekaterina S. Menchinskaya Ekaterina A. Chingizova Shamil S. Afiyatullov Ekaterina A. Yurchenko Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of <i>Aspergillus</i> and <i>Penicillium</i> Genera Marine Drugs <i>Aspergillus terreus</i> <i>Aspergillus flocculosus</i> <i>Penicillium</i> sp. marine-derived fungi South China Sea secondary metabolites |
| title | Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of <i>Aspergillus</i> and <i>Penicillium</i> Genera |
| title_full | Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of <i>Aspergillus</i> and <i>Penicillium</i> Genera |
| title_fullStr | Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of <i>Aspergillus</i> and <i>Penicillium</i> Genera |
| title_full_unstemmed | Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of <i>Aspergillus</i> and <i>Penicillium</i> Genera |
| title_short | Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of <i>Aspergillus</i> and <i>Penicillium</i> Genera |
| title_sort | neuroprotective metabolites from vietnamese marine derived fungi of i aspergillus i and i penicillium i genera |
| topic | <i>Aspergillus terreus</i> <i>Aspergillus flocculosus</i> <i>Penicillium</i> sp. marine-derived fungi South China Sea secondary metabolites |
| url | https://www.mdpi.com/1660-3397/18/12/608 |
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