Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies
Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired circadian rhythms are associated with mental disorders. The evening chronotype, which is linked to circadian misalignment, is a risk factor for severe psychiatric...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7579 |
| _version_ | 1797605029330288640 |
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| author | Pilar Codoñer-Franch Marie Gombert José Martínez-Raga María Carmen Cenit |
| author_facet | Pilar Codoñer-Franch Marie Gombert José Martínez-Raga María Carmen Cenit |
| author_sort | Pilar Codoñer-Franch |
| collection | DOAJ |
| description | Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired circadian rhythms are associated with mental disorders. The evening chronotype, which is linked to circadian misalignment, is a risk factor for severe psychiatric symptoms and psychiatric metabolic comorbidities. Resynchronization of circadian rhythms commonly improves psychiatric symptoms. Furthermore, evidence indicates that preventing circadian misalignment may help reduce the risk of psychiatric disorders and the impact of neuro–immuno–metabolic disturbances in psychiatry. The gut microbiota exhibits diurnal rhythmicity, as largely governed by meal timing, which regulates the host’s circadian rhythms. Temporal circadian regulation of feeding has emerged as a promising chronotherapeutic strategy to prevent and/or help with the treatment of mental illnesses, largely through the modulation of gut microbiota. Here, we provide an overview of the link between circadian disruption and mental illness. We summarize the connection between gut microbiota and circadian rhythms, supporting the idea that gut microbiota modulation may aid in preventing circadian misalignment and in the resynchronization of disrupted circadian rhythms. We describe diurnal microbiome rhythmicity and its related factors, highlighting the role of meal timing. Lastly, we emphasize the necessity and rationale for further research to develop effective and safe microbiome and dietary strategies based on chrononutrition to combat mental illness. |
| first_indexed | 2024-03-11T04:55:19Z |
| format | Article |
| id | doaj.art-9dbb5f7dacff4bb282af73f8a7a8f358 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:55:19Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9dbb5f7dacff4bb282af73f8a7a8f3582023-11-17T19:42:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248757910.3390/ijms24087579Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary StrategiesPilar Codoñer-Franch0Marie Gombert1José Martínez-Raga2María Carmen Cenit3Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, 46010 Valencia, SpainBiosciences Division, Center for Health Sciences, SRI International, Menlo Park, CA 94025, USADepartment of Psychiatry and Clinical Psychology, Hospital Universitario Doctor Peset, University of Valencia, 46017 Valencia, SpainMicrobial Ecology, Nutrition & Health Research Unit, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), 46980 Valencia, SpainMental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired circadian rhythms are associated with mental disorders. The evening chronotype, which is linked to circadian misalignment, is a risk factor for severe psychiatric symptoms and psychiatric metabolic comorbidities. Resynchronization of circadian rhythms commonly improves psychiatric symptoms. Furthermore, evidence indicates that preventing circadian misalignment may help reduce the risk of psychiatric disorders and the impact of neuro–immuno–metabolic disturbances in psychiatry. The gut microbiota exhibits diurnal rhythmicity, as largely governed by meal timing, which regulates the host’s circadian rhythms. Temporal circadian regulation of feeding has emerged as a promising chronotherapeutic strategy to prevent and/or help with the treatment of mental illnesses, largely through the modulation of gut microbiota. Here, we provide an overview of the link between circadian disruption and mental illness. We summarize the connection between gut microbiota and circadian rhythms, supporting the idea that gut microbiota modulation may aid in preventing circadian misalignment and in the resynchronization of disrupted circadian rhythms. We describe diurnal microbiome rhythmicity and its related factors, highlighting the role of meal timing. Lastly, we emphasize the necessity and rationale for further research to develop effective and safe microbiome and dietary strategies based on chrononutrition to combat mental illness.https://www.mdpi.com/1422-0067/24/8/7579circadian rhythmchronodisruptionchrononutritionchronotypetime restricted feedingdiet |
| spellingShingle | Pilar Codoñer-Franch Marie Gombert José Martínez-Raga María Carmen Cenit Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies International Journal of Molecular Sciences circadian rhythm chronodisruption chrononutrition chronotype time restricted feeding diet |
| title | Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies |
| title_full | Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies |
| title_fullStr | Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies |
| title_full_unstemmed | Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies |
| title_short | Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies |
| title_sort | circadian disruption and mental health the chronotherapeutic potential of microbiome based and dietary strategies |
| topic | circadian rhythm chronodisruption chrononutrition chronotype time restricted feeding diet |
| url | https://www.mdpi.com/1422-0067/24/8/7579 |
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