A novel misoprostol delivery system for induction of labor: clinical utility and patient considerations
Megan L Stephenson, Deborah A WingDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Irvine Medical Center, Orange, CA, USAAbstract: Induction of labor is one of the most commonly performed obstetric procedures and will likely become more...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2015-04-01
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| Series: | Drug Design, Development and Therapy |
| Online Access: | http://www.dovepress.com/a-novel-misoprostol-delivery-system-for-induction-of-labor-clinical-ut-peer-reviewed-article-DDDT |
| _version_ | 1819127493235310592 |
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| author | Stephenson ML Wing DA |
| author_facet | Stephenson ML Wing DA |
| author_sort | Stephenson ML |
| collection | DOAJ |
| description | Megan L Stephenson, Deborah A WingDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Irvine Medical Center, Orange, CA, USAAbstract: Induction of labor is one of the most commonly performed obstetric procedures and will likely become more common as the reproductive population in developed nations changes. As the proportion of women undergoing induction grows, there is a constant search for more efficacious ways to induce labor while maintaining fetal and maternal safety as well as patient satisfaction. With almost half of induced labors requiring cervical ripening, methods for achieving active labor and vaginal delivery are constantly being investigated. Prostaglandins have been shown to be effective induction agents, and specifically vaginal misoprostol, used off-label, have been widely utilized to initiate cervical ripening and active labor. The challenge is to administer this medication accurately while maintaining the ability to discontinue the medication when needed. The misoprostol vaginal insert initiates cervical ripening utilizing a delivery system that controls medication release and can be rapidly removed. This paper reviews the design, development, and clinical utility of the misoprostol vaginal insert for induction of labor as well as patient considerations related to the delivery system.Keywords: misoprostol, induction, cervical ripening, vaginal insert |
| first_indexed | 2024-12-22T08:12:48Z |
| format | Article |
| id | doaj.art-9dbbce24ebb14c6c91e2a9634e46dfbf |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-22T08:12:48Z |
| publishDate | 2015-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-9dbbce24ebb14c6c91e2a9634e46dfbf2022-12-21T18:32:59ZengDove Medical PressDrug Design, Development and Therapy1177-88812015-04-012015default2321232721458A novel misoprostol delivery system for induction of labor: clinical utility and patient considerationsStephenson MLWing DAMegan L Stephenson, Deborah A WingDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Irvine Medical Center, Orange, CA, USAAbstract: Induction of labor is one of the most commonly performed obstetric procedures and will likely become more common as the reproductive population in developed nations changes. As the proportion of women undergoing induction grows, there is a constant search for more efficacious ways to induce labor while maintaining fetal and maternal safety as well as patient satisfaction. With almost half of induced labors requiring cervical ripening, methods for achieving active labor and vaginal delivery are constantly being investigated. Prostaglandins have been shown to be effective induction agents, and specifically vaginal misoprostol, used off-label, have been widely utilized to initiate cervical ripening and active labor. The challenge is to administer this medication accurately while maintaining the ability to discontinue the medication when needed. The misoprostol vaginal insert initiates cervical ripening utilizing a delivery system that controls medication release and can be rapidly removed. This paper reviews the design, development, and clinical utility of the misoprostol vaginal insert for induction of labor as well as patient considerations related to the delivery system.Keywords: misoprostol, induction, cervical ripening, vaginal inserthttp://www.dovepress.com/a-novel-misoprostol-delivery-system-for-induction-of-labor-clinical-ut-peer-reviewed-article-DDDT |
| spellingShingle | Stephenson ML Wing DA A novel misoprostol delivery system for induction of labor: clinical utility and patient considerations Drug Design, Development and Therapy |
| title | A novel misoprostol delivery system for induction of labor: clinical utility and patient considerations |
| title_full | A novel misoprostol delivery system for induction of labor: clinical utility and patient considerations |
| title_fullStr | A novel misoprostol delivery system for induction of labor: clinical utility and patient considerations |
| title_full_unstemmed | A novel misoprostol delivery system for induction of labor: clinical utility and patient considerations |
| title_short | A novel misoprostol delivery system for induction of labor: clinical utility and patient considerations |
| title_sort | novel misoprostol delivery system for induction of labor clinical utility and patient considerations |
| url | http://www.dovepress.com/a-novel-misoprostol-delivery-system-for-induction-of-labor-clinical-ut-peer-reviewed-article-DDDT |
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