Systematic error in hippocampal volume asymmetry measurement is minimal with a manual segmentation protocol
Hemispheric asymmetry of hippocampal volume is a common finding that has biological relevance, including associations with dementia and cognitive performance. However, a recent study has reported the possibility of systematic error in measurements of hippocampal asymmetry by magnetic resonance volum...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-12-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00179/full |
| _version_ | 1818349288641527808 |
|---|---|
| author | Baxter P Rogers Baxter P Rogers Julia M Sheffield Andrew S Luksik Stephan eHeckers |
| author_facet | Baxter P Rogers Baxter P Rogers Julia M Sheffield Andrew S Luksik Stephan eHeckers |
| author_sort | Baxter P Rogers |
| collection | DOAJ |
| description | Hemispheric asymmetry of hippocampal volume is a common finding that has biological relevance, including associations with dementia and cognitive performance. However, a recent study has reported the possibility of systematic error in measurements of hippocampal asymmetry by magnetic resonance volumetry. We manually traced the volumes of the anterior and posterior hippocampus in 40 healthy people to measure systematic error related to image orientation. We found a bias due to the side of the screen on which the hippocampus was viewed, such that hippocampal volume was larger when traced on the left side of the screen than when traced on the right (p=0.05). However, this bias was smaller than the anatomical right > left asymmetry of the anterior hippocampus (p=0.004). We found right>left asymmetry of hippocampal volume regardless of image presentation (radiological versus neurological). We conclude that manual segmentation protocols can minimize the effect of image orientation in the study of hippocampal volume asymmetry, but our confirmation that such bias exists suggests strategies to avoid it in future studies. |
| first_indexed | 2024-12-13T18:03:34Z |
| format | Article |
| id | doaj.art-9dbcf43b2e9444c8951b69bfd45cf9e1 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-13T18:03:34Z |
| publishDate | 2012-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-9dbcf43b2e9444c8951b69bfd45cf9e12022-12-21T23:36:08ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2012-12-01610.3389/fnins.2012.0017932913Systematic error in hippocampal volume asymmetry measurement is minimal with a manual segmentation protocolBaxter P Rogers0Baxter P Rogers1Julia M Sheffield2Andrew S Luksik3Stephan eHeckers4Vanderbilt UniversityVanderbilt UniversityVanderbilt UniversityVanderbilt UniversityVanderbilt UniversityHemispheric asymmetry of hippocampal volume is a common finding that has biological relevance, including associations with dementia and cognitive performance. However, a recent study has reported the possibility of systematic error in measurements of hippocampal asymmetry by magnetic resonance volumetry. We manually traced the volumes of the anterior and posterior hippocampus in 40 healthy people to measure systematic error related to image orientation. We found a bias due to the side of the screen on which the hippocampus was viewed, such that hippocampal volume was larger when traced on the left side of the screen than when traced on the right (p=0.05). However, this bias was smaller than the anatomical right > left asymmetry of the anterior hippocampus (p=0.004). We found right>left asymmetry of hippocampal volume regardless of image presentation (radiological versus neurological). We conclude that manual segmentation protocols can minimize the effect of image orientation in the study of hippocampal volume asymmetry, but our confirmation that such bias exists suggests strategies to avoid it in future studies.http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00179/fullHippocampusasymmetrysegmentationasymmetry biasMRI volumetry |
| spellingShingle | Baxter P Rogers Baxter P Rogers Julia M Sheffield Andrew S Luksik Stephan eHeckers Systematic error in hippocampal volume asymmetry measurement is minimal with a manual segmentation protocol Frontiers in Neuroscience Hippocampus asymmetry segmentation asymmetry bias MRI volumetry |
| title | Systematic error in hippocampal volume asymmetry measurement is minimal with a manual segmentation protocol |
| title_full | Systematic error in hippocampal volume asymmetry measurement is minimal with a manual segmentation protocol |
| title_fullStr | Systematic error in hippocampal volume asymmetry measurement is minimal with a manual segmentation protocol |
| title_full_unstemmed | Systematic error in hippocampal volume asymmetry measurement is minimal with a manual segmentation protocol |
| title_short | Systematic error in hippocampal volume asymmetry measurement is minimal with a manual segmentation protocol |
| title_sort | systematic error in hippocampal volume asymmetry measurement is minimal with a manual segmentation protocol |
| topic | Hippocampus asymmetry segmentation asymmetry bias MRI volumetry |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00179/full |
| work_keys_str_mv | AT baxterprogers systematicerrorinhippocampalvolumeasymmetrymeasurementisminimalwithamanualsegmentationprotocol AT baxterprogers systematicerrorinhippocampalvolumeasymmetrymeasurementisminimalwithamanualsegmentationprotocol AT juliamsheffield systematicerrorinhippocampalvolumeasymmetrymeasurementisminimalwithamanualsegmentationprotocol AT andrewsluksik systematicerrorinhippocampalvolumeasymmetrymeasurementisminimalwithamanualsegmentationprotocol AT stephaneheckers systematicerrorinhippocampalvolumeasymmetrymeasurementisminimalwithamanualsegmentationprotocol |