The two-component adjuvant IC31® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs.

The two-component adjuvant IC31® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs.

The aim of this study was to characterize and identify the mode of action of IC31®, a two-component vaccine adjuvant. We found that IC31® was accumulated in human peripheral blood monocytes, MHC class II positive cells and monocyte-derived DCs (moDCs) but not in plasmacytoid DCs (pDCs). In the prese...

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Bibliographic Details
Main Authors: Attila Szabo, Peter Gogolak, Kitti Pazmandi, Katalin Kis-Toth, Karin Riedl, Benjamin Wizel, Karen Lingnau, Attila Bacsi, Bence Rethi, Eva Rajnavolgyi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3566214?pdf=render

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