Complement System Inhibition Modulates the Pro-Inflammatory Effects of a Snake Venom Metalloproteinase

Complement System Inhibition Modulates the Pro-Inflammatory Effects of a Snake Venom Metalloproteinase

Envenomation by Bothrops snakes causes prominent local effects, including pain, oedema, local bleeding, blistering and necrosis, and systemic manifestations, such as hemorrhage, hypotension, shock and acute renal failure. These snake venoms are able to activate the complement system and induce the g...

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Bibliographic Details
Main Authors: Lygia Samartin Gonçalves Luchini, Giselle Pidde, Carla Cristina Squaiella-Baptistão, Denise V. Tambourgi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
Bothrops pirajai
SVMP
complement system
whole blood model
compstatin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01137/full

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