Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature
Solid tumors are dependent on vascularization for their growth. The hypoxic, stiff, and pro-angiogenic tumor microenvironment induces angiogenesis, giving rise to an immature, proliferative, and permeable vasculature. The tumor vessels promote tumor metastasis and complicate delivery of anti-cancer...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-02-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.612802/full |
| _version_ | 1818929807085273088 |
|---|---|
| author | Aukie Hooglugt Aukie Hooglugt Miesje M. van der Stoel Reinier A. Boon Reinier A. Boon Reinier A. Boon Stephan Huveneers |
| author_facet | Aukie Hooglugt Aukie Hooglugt Miesje M. van der Stoel Reinier A. Boon Reinier A. Boon Reinier A. Boon Stephan Huveneers |
| author_sort | Aukie Hooglugt |
| collection | DOAJ |
| description | Solid tumors are dependent on vascularization for their growth. The hypoxic, stiff, and pro-angiogenic tumor microenvironment induces angiogenesis, giving rise to an immature, proliferative, and permeable vasculature. The tumor vessels promote tumor metastasis and complicate delivery of anti-cancer therapies. In many types of tumors, YAP/TAZ activation is correlated with increased levels of angiogenesis. In addition, endothelial YAP/TAZ activation is important for the formation of new blood and lymphatic vessels during development. Oncogenic activation of YAP/TAZ in tumor cell growth and invasion has been studied in great detail, however the role of YAP/TAZ within the tumor endothelium remains insufficiently understood, which complicates therapeutic strategies aimed at targeting YAP/TAZ in cancer. Here, we overview the upstream signals from the tumor microenvironment that control endothelial YAP/TAZ activation and explore the role of their downstream targets in driving tumor angiogenesis. We further discuss the potential for anti-cancer treatments and vascular normalization strategies to improve tumor therapies. |
| first_indexed | 2024-12-20T03:50:40Z |
| format | Article |
| id | doaj.art-9dbed76ab279403286c5b8bfc2c64e02 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T03:50:40Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9dbed76ab279403286c5b8bfc2c64e022022-12-21T19:54:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011010.3389/fonc.2020.612802612802Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor VasculatureAukie Hooglugt0Aukie Hooglugt1Miesje M. van der Stoel2Reinier A. Boon3Reinier A. Boon4Reinier A. Boon5Stephan Huveneers6Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, NetherlandsDepartment of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University Medical Center, Amsterdam, NetherlandsDepartment of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, NetherlandsDepartment of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University Medical Center, Amsterdam, NetherlandsGerman Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, Berlin, GermanyInstitute of Cardiovascular Regeneration, Goethe University, Frankfurt am Main, GermanyDepartment of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, NetherlandsSolid tumors are dependent on vascularization for their growth. The hypoxic, stiff, and pro-angiogenic tumor microenvironment induces angiogenesis, giving rise to an immature, proliferative, and permeable vasculature. The tumor vessels promote tumor metastasis and complicate delivery of anti-cancer therapies. In many types of tumors, YAP/TAZ activation is correlated with increased levels of angiogenesis. In addition, endothelial YAP/TAZ activation is important for the formation of new blood and lymphatic vessels during development. Oncogenic activation of YAP/TAZ in tumor cell growth and invasion has been studied in great detail, however the role of YAP/TAZ within the tumor endothelium remains insufficiently understood, which complicates therapeutic strategies aimed at targeting YAP/TAZ in cancer. Here, we overview the upstream signals from the tumor microenvironment that control endothelial YAP/TAZ activation and explore the role of their downstream targets in driving tumor angiogenesis. We further discuss the potential for anti-cancer treatments and vascular normalization strategies to improve tumor therapies.https://www.frontiersin.org/articles/10.3389/fonc.2020.612802/fullyes-associated protein (YAP)TAZtumor vasculatureendotheliummechanotransductioncancer |
| spellingShingle | Aukie Hooglugt Aukie Hooglugt Miesje M. van der Stoel Reinier A. Boon Reinier A. Boon Reinier A. Boon Stephan Huveneers Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature Frontiers in Oncology yes-associated protein (YAP) TAZ tumor vasculature endothelium mechanotransduction cancer |
| title | Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature |
| title_full | Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature |
| title_fullStr | Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature |
| title_full_unstemmed | Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature |
| title_short | Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature |
| title_sort | endothelial yap taz signaling in angiogenesis and tumor vasculature |
| topic | yes-associated protein (YAP) TAZ tumor vasculature endothelium mechanotransduction cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.612802/full |
| work_keys_str_mv | AT aukiehooglugt endothelialyaptazsignalinginangiogenesisandtumorvasculature AT aukiehooglugt endothelialyaptazsignalinginangiogenesisandtumorvasculature AT miesjemvanderstoel endothelialyaptazsignalinginangiogenesisandtumorvasculature AT reinieraboon endothelialyaptazsignalinginangiogenesisandtumorvasculature AT reinieraboon endothelialyaptazsignalinginangiogenesisandtumorvasculature AT reinieraboon endothelialyaptazsignalinginangiogenesisandtumorvasculature AT stephanhuveneers endothelialyaptazsignalinginangiogenesisandtumorvasculature |