Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature

Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature

Solid tumors are dependent on vascularization for their growth. The hypoxic, stiff, and pro-angiogenic tumor microenvironment induces angiogenesis, giving rise to an immature, proliferative, and permeable vasculature. The tumor vessels promote tumor metastasis and complicate delivery of anti-cancer...

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Bibliographic Details
Main Authors: Aukie Hooglugt, Miesje M. van der Stoel, Reinier A. Boon, Stephan Huveneers
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
yes-associated protein (YAP)
TAZ
tumor vasculature
endothelium
mechanotransduction
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.612802/full

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