LMP1-Positive Composite Tumour of Larynx: A Diagnostic Quandary
Malignant spindle cell tumours of the larynx are rare, of which the most common are Spindle Cell Squamous Carcinomas (SCSCs). Sarcomas are extremely infrequent in the larynx. Composite tumours, further, are quite unheard of, except for rare case reports. This case report describes a spindle cell mal...
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JCDR Research and Publications Private Limited
2018-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/12229/38005_CE[Ra1]_F(SL)_PF1(AJ_SL)_PN(SHU).pdf |
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| author | Kausalya Kumari Sahu Saraswathy Sreeram Panduranga Kamath Vijendra Shenoy Nimi Mohammed Ali |
| author_facet | Kausalya Kumari Sahu Saraswathy Sreeram Panduranga Kamath Vijendra Shenoy Nimi Mohammed Ali |
| author_sort | Kausalya Kumari Sahu |
| collection | DOAJ |
| description | Malignant spindle cell tumours of the larynx are rare, of which the most common are Spindle Cell Squamous Carcinomas (SCSCs). Sarcomas are extremely infrequent in the larynx. Composite tumours, further, are quite unheard of, except for rare case reports. This case report describes a spindle cell malignancy of the larynx in an elderly male, which posed a diagnostic difficulty due to its unique morphological and immunohistochemical features. The tumour was superficial, polypoidal with the proliferation of malignant spindle cells and abundant mitoses under an ulcerated epithelium. Occasional squamous cell rests with keratin pearls were present. Spindle cells were strongly immunoreactive for vimentin, smooth muscle actin and squamoid cells were p63 positive. Desmin was negative. The dilemma in diagnosis was of a SCSC with smooth muscle differentiation against a composite tumour. The tumour also turned out to be positive for Epstein Barr Virus Latent Membrane Protein-1 (EBV-LMP1), establishing a noteworthy association. |
| first_indexed | 2024-04-14T07:42:23Z |
| format | Article |
| id | doaj.art-9dc0823b0b9c4a74bc49f7edd16244d2 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-14T07:42:23Z |
| publishDate | 2018-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-9dc0823b0b9c4a74bc49f7edd16244d22022-12-22T02:05:26ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-11-011211ED01ED0310.7860/JCDR/2018/38005.12229LMP1-Positive Composite Tumour of Larynx: A Diagnostic QuandaryKausalya Kumari Sahu0Saraswathy Sreeram1Panduranga Kamath2Vijendra Shenoy3Nimi Mohammed Ali4Professor, Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.Assistant Professor, Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.Professor, Department of Otorhinolaryngology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.Professor and Head, Department of Otorhinolaryngology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.Junior Resident, Department of Otorhinolaryngology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India.Malignant spindle cell tumours of the larynx are rare, of which the most common are Spindle Cell Squamous Carcinomas (SCSCs). Sarcomas are extremely infrequent in the larynx. Composite tumours, further, are quite unheard of, except for rare case reports. This case report describes a spindle cell malignancy of the larynx in an elderly male, which posed a diagnostic difficulty due to its unique morphological and immunohistochemical features. The tumour was superficial, polypoidal with the proliferation of malignant spindle cells and abundant mitoses under an ulcerated epithelium. Occasional squamous cell rests with keratin pearls were present. Spindle cells were strongly immunoreactive for vimentin, smooth muscle actin and squamoid cells were p63 positive. Desmin was negative. The dilemma in diagnosis was of a SCSC with smooth muscle differentiation against a composite tumour. The tumour also turned out to be positive for Epstein Barr Virus Latent Membrane Protein-1 (EBV-LMP1), establishing a noteworthy association.https://jcdr.net/articles/PDF/12229/38005_CE[Ra1]_F(SL)_PF1(AJ_SL)_PN(SHU).pdflaryngeal malignancyleiomyosarcomaspindle cellssquamous cell carcinoma |
| spellingShingle | Kausalya Kumari Sahu Saraswathy Sreeram Panduranga Kamath Vijendra Shenoy Nimi Mohammed Ali LMP1-Positive Composite Tumour of Larynx: A Diagnostic Quandary Journal of Clinical and Diagnostic Research laryngeal malignancy leiomyosarcoma spindle cells squamous cell carcinoma |
| title | LMP1-Positive Composite Tumour of Larynx: A Diagnostic Quandary |
| title_full | LMP1-Positive Composite Tumour of Larynx: A Diagnostic Quandary |
| title_fullStr | LMP1-Positive Composite Tumour of Larynx: A Diagnostic Quandary |
| title_full_unstemmed | LMP1-Positive Composite Tumour of Larynx: A Diagnostic Quandary |
| title_short | LMP1-Positive Composite Tumour of Larynx: A Diagnostic Quandary |
| title_sort | lmp1 positive composite tumour of larynx a diagnostic quandary |
| topic | laryngeal malignancy leiomyosarcoma spindle cells squamous cell carcinoma |
| url | https://jcdr.net/articles/PDF/12229/38005_CE[Ra1]_F(SL)_PF1(AJ_SL)_PN(SHU).pdf |
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