Correlation of peripapillary retinal nerve fiber layer and macular ganglion cell–inner plexiform layer in early to moderate glaucoma using the Cirrus® widefield analysis (PanoMap®)
Purpose: To evaluate and correlate the structural changes between peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell layer (GCL) + inner plexiform layer (IPL) in different stages of glaucoma using PanoMap® optical coherence tomography (OCT). Design: Retrospective observational...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2024;volume=72;issue=3;spage=412;epage=416;aulast=O |
| _version_ | 1797246466481192960 |
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| author | Patricia Camille O Acosta John Mark S de Leon |
| author_facet | Patricia Camille O Acosta John Mark S de Leon |
| author_sort | Patricia Camille O Acosta |
| collection | DOAJ |
| description | Purpose: To evaluate and correlate the structural changes between peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell layer (GCL) + inner plexiform layer (IPL) in different stages of glaucoma using PanoMap® optical coherence tomography (OCT). Design: Retrospective observational study. Methods: Glaucoma diagnostic test data were collected from early to moderate open-angle glaucoma patients. The average and minimum GCL + IPL thickness, sectoral GCL + IPL thickness, and the average and sectoral RNFL thickness were correlated with the different glaucoma stages. Results: This study included 157 eyes from 157 glaucoma patients. Patients were grouped into pre-perimetric, early, and moderate glaucoma. The mean average RNFL thickness, RNFL thickness per sector, average GCL + IPL thickness, and minimum GCL + IPL thickness were different between the three groups (P < 0.001), except for the nasal sector (P = 0.643).The mean GCL + IPL thickness in all six sectors showed differences between the groups (P < 0.001), except the superonasal sector (P < 0.002).The inferior GCL + IPL sector is the thinnest, followed by the inferotemporal sector. There was a strong correlation between the mean average RNFL and the average GCL + IPL thickness in the pre-perimetric group (r = 0.4963, P < 0.001) and the moderate group (r = 0.6534, P < 0.001).The early glaucoma group did not show significant correlation (r = 0.2963, P = 0.0536). Conclusion: Peripapillary RNFL and macular GCL + IPL thinning was evident in different stages of glaucoma, with more thinning observed with increasing glaucoma severity. The peripapillary RNFL and macular GCL + IPL average thickness values were highly correlated in the pre-perimetric and moderate stages of glaucoma. |
| first_indexed | 2024-04-24T19:43:15Z |
| format | Article |
| id | doaj.art-9dc309349f824dc4b838c981b6d938a0 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-04-24T19:43:15Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-9dc309349f824dc4b838c981b6d938a02024-03-25T10:28:45ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892024-01-0172341241610.4103/IJO.IJO_697_23Correlation of peripapillary retinal nerve fiber layer and macular ganglion cell–inner plexiform layer in early to moderate glaucoma using the Cirrus® widefield analysis (PanoMap®)Patricia Camille O AcostaJohn Mark S de LeonPurpose: To evaluate and correlate the structural changes between peripapillary retinal nerve fiber layer (RNFL) and macular ganglion cell layer (GCL) + inner plexiform layer (IPL) in different stages of glaucoma using PanoMap® optical coherence tomography (OCT). Design: Retrospective observational study. Methods: Glaucoma diagnostic test data were collected from early to moderate open-angle glaucoma patients. The average and minimum GCL + IPL thickness, sectoral GCL + IPL thickness, and the average and sectoral RNFL thickness were correlated with the different glaucoma stages. Results: This study included 157 eyes from 157 glaucoma patients. Patients were grouped into pre-perimetric, early, and moderate glaucoma. The mean average RNFL thickness, RNFL thickness per sector, average GCL + IPL thickness, and minimum GCL + IPL thickness were different between the three groups (P < 0.001), except for the nasal sector (P = 0.643).The mean GCL + IPL thickness in all six sectors showed differences between the groups (P < 0.001), except the superonasal sector (P < 0.002).The inferior GCL + IPL sector is the thinnest, followed by the inferotemporal sector. There was a strong correlation between the mean average RNFL and the average GCL + IPL thickness in the pre-perimetric group (r = 0.4963, P < 0.001) and the moderate group (r = 0.6534, P < 0.001).The early glaucoma group did not show significant correlation (r = 0.2963, P = 0.0536). Conclusion: Peripapillary RNFL and macular GCL + IPL thinning was evident in different stages of glaucoma, with more thinning observed with increasing glaucoma severity. The peripapillary RNFL and macular GCL + IPL average thickness values were highly correlated in the pre-perimetric and moderate stages of glaucoma.http://www.ijo.in/article.asp?issn=0301-4738;year=2024;volume=72;issue=3;spage=412;epage=416;aulast=Oglaucomaoctpanomap |
| spellingShingle | Patricia Camille O Acosta John Mark S de Leon Correlation of peripapillary retinal nerve fiber layer and macular ganglion cell–inner plexiform layer in early to moderate glaucoma using the Cirrus® widefield analysis (PanoMap®) Indian Journal of Ophthalmology glaucoma oct panomap |
| title | Correlation of peripapillary retinal nerve fiber layer and macular ganglion cell–inner plexiform layer in early to moderate glaucoma using the Cirrus® widefield analysis (PanoMap®) |
| title_full | Correlation of peripapillary retinal nerve fiber layer and macular ganglion cell–inner plexiform layer in early to moderate glaucoma using the Cirrus® widefield analysis (PanoMap®) |
| title_fullStr | Correlation of peripapillary retinal nerve fiber layer and macular ganglion cell–inner plexiform layer in early to moderate glaucoma using the Cirrus® widefield analysis (PanoMap®) |
| title_full_unstemmed | Correlation of peripapillary retinal nerve fiber layer and macular ganglion cell–inner plexiform layer in early to moderate glaucoma using the Cirrus® widefield analysis (PanoMap®) |
| title_short | Correlation of peripapillary retinal nerve fiber layer and macular ganglion cell–inner plexiform layer in early to moderate glaucoma using the Cirrus® widefield analysis (PanoMap®) |
| title_sort | correlation of peripapillary retinal nerve fiber layer and macular ganglion cell inner plexiform layer in early to moderate glaucoma using the cirrus r widefield analysis panomap r |
| topic | glaucoma oct panomap |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2024;volume=72;issue=3;spage=412;epage=416;aulast=O |
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