Temperature-Responsive Hydrogel-Coated Gold Nanoshells
Gold nanoshells (~160 nm in diameter) were encapsulated within a shell of temperature-responsive poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) using a surface-bound rationally-designed free radical initiator in water for the development of a photothermally-induced drug-delivery system...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-03-01
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| Series: | Gels |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2310-2861/4/2/28 |
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| author | Hye Hun Park La-ongnuan Srisombat Andrew C. Jamison Tingting Liu Maria D. Marquez Hansoo Park Sungbae Lee Tai-Chou Lee T. Randall Lee |
| author_facet | Hye Hun Park La-ongnuan Srisombat Andrew C. Jamison Tingting Liu Maria D. Marquez Hansoo Park Sungbae Lee Tai-Chou Lee T. Randall Lee |
| author_sort | Hye Hun Park |
| collection | DOAJ |
| description | Gold nanoshells (~160 nm in diameter) were encapsulated within a shell of temperature-responsive poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) using a surface-bound rationally-designed free radical initiator in water for the development of a photothermally-induced drug-delivery system. The morphologies of the resultant hydrogel-coated nanoshells were analyzed by scanning electron microscopy (SEM), while the temperature-responsive behavior of the nanoparticles was characterized by dynamic light scattering (DLS). The diameter of the P(NIPAM-co-AA) encapsulated nanoshells decreased as the solution temperature was increased, indicating a collapse of the hydrogel layer with increasing temperatures. In addition, the optical properties of the composite nanoshells were studied by UV-visible spectroscopy. The surface plasmon resonance (SPR) peak of the hydrogel-coated nanoshells appeared at ~800 nm, which lies within the tissue-transparent range that is important for biomedical applications. Furthermore, the periphery of the particles was conjugated with the model protein avidin to modify the hydrogel-coated nanoshells with a fluorescent-tagged biotin, biotin-4-fluorescein (biotin-4-FITC), for colorimetric imaging/monitoring. |
| first_indexed | 2024-04-12T00:17:13Z |
| format | Article |
| id | doaj.art-9dc3bad450fc4d91aad25d8e95087ddd |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-04-12T00:17:13Z |
| publishDate | 2018-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-9dc3bad450fc4d91aad25d8e95087ddd2022-12-22T03:55:49ZengMDPI AGGels2310-28612018-03-01422810.3390/gels4020028gels4020028Temperature-Responsive Hydrogel-Coated Gold NanoshellsHye Hun Park0La-ongnuan Srisombat1Andrew C. Jamison2Tingting Liu3Maria D. Marquez4Hansoo Park5Sungbae Lee6Tai-Chou Lee7T. Randall Lee8Department of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204-5003, USADepartment of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204-5003, USADepartment of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204-5003, USADepartment of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204-5003, USADepartment of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204-5003, USASchool of Integrative Engineering, Chung-Ang University, Seoul 156-756, KoreaDepartments of Physics and Photon Science, Gwangju Institute of Science and Technology, 123 Chemdan-gwagiro (Oryong-dong), Buk-gu, Gwangju 500-712, KoreaDepartment of Chemical and Materials Engineering, National Central University, 300 Jhongda Road, Jhongli City 32001, TaiwanDepartment of Chemistry and the Texas Center for Superconductivity, University of Houston, Houston, TX 77204-5003, USAGold nanoshells (~160 nm in diameter) were encapsulated within a shell of temperature-responsive poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) using a surface-bound rationally-designed free radical initiator in water for the development of a photothermally-induced drug-delivery system. The morphologies of the resultant hydrogel-coated nanoshells were analyzed by scanning electron microscopy (SEM), while the temperature-responsive behavior of the nanoparticles was characterized by dynamic light scattering (DLS). The diameter of the P(NIPAM-co-AA) encapsulated nanoshells decreased as the solution temperature was increased, indicating a collapse of the hydrogel layer with increasing temperatures. In addition, the optical properties of the composite nanoshells were studied by UV-visible spectroscopy. The surface plasmon resonance (SPR) peak of the hydrogel-coated nanoshells appeared at ~800 nm, which lies within the tissue-transparent range that is important for biomedical applications. Furthermore, the periphery of the particles was conjugated with the model protein avidin to modify the hydrogel-coated nanoshells with a fluorescent-tagged biotin, biotin-4-fluorescein (biotin-4-FITC), for colorimetric imaging/monitoring.http://www.mdpi.com/2310-2861/4/2/28drug deliverytemperature responsivegold nanoshellhydrogel coating |
| spellingShingle | Hye Hun Park La-ongnuan Srisombat Andrew C. Jamison Tingting Liu Maria D. Marquez Hansoo Park Sungbae Lee Tai-Chou Lee T. Randall Lee Temperature-Responsive Hydrogel-Coated Gold Nanoshells Gels drug delivery temperature responsive gold nanoshell hydrogel coating |
| title | Temperature-Responsive Hydrogel-Coated Gold Nanoshells |
| title_full | Temperature-Responsive Hydrogel-Coated Gold Nanoshells |
| title_fullStr | Temperature-Responsive Hydrogel-Coated Gold Nanoshells |
| title_full_unstemmed | Temperature-Responsive Hydrogel-Coated Gold Nanoshells |
| title_short | Temperature-Responsive Hydrogel-Coated Gold Nanoshells |
| title_sort | temperature responsive hydrogel coated gold nanoshells |
| topic | drug delivery temperature responsive gold nanoshell hydrogel coating |
| url | http://www.mdpi.com/2310-2861/4/2/28 |
| work_keys_str_mv | AT hyehunpark temperatureresponsivehydrogelcoatedgoldnanoshells AT laongnuansrisombat temperatureresponsivehydrogelcoatedgoldnanoshells AT andrewcjamison temperatureresponsivehydrogelcoatedgoldnanoshells AT tingtingliu temperatureresponsivehydrogelcoatedgoldnanoshells AT mariadmarquez temperatureresponsivehydrogelcoatedgoldnanoshells AT hansoopark temperatureresponsivehydrogelcoatedgoldnanoshells AT sungbaelee temperatureresponsivehydrogelcoatedgoldnanoshells AT taichoulee temperatureresponsivehydrogelcoatedgoldnanoshells AT trandalllee temperatureresponsivehydrogelcoatedgoldnanoshells |