The cut-off value for HOMA-IR discriminating the insulin resistance based on the SHBG level in women with polycystic ovary syndrome
IntroductionThe study aimed to estimate the cut-off value for homeostatic model assessment for insulin resistance (HOMA-IR) discriminating the insulin resistance based on the sex hormones binding globulin (SHBG) level in women with polycystic ovary syndrome (PCOS).Materials and methodsData from medi...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1100547/full |
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| author | Aleksandra Biernacka-Bartnik Piotr Kocełak Aleksander Jerzy Owczarek Piotr Stanisław Choręza Leszek Markuszewski Paweł Madej Monika Puzianowska-Kuźnicka Monika Puzianowska-Kuźnicka Jerzy Chudek Jerzy Chudek Magdalena Olszanecka-Glinianowicz |
| author_facet | Aleksandra Biernacka-Bartnik Piotr Kocełak Aleksander Jerzy Owczarek Piotr Stanisław Choręza Leszek Markuszewski Paweł Madej Monika Puzianowska-Kuźnicka Monika Puzianowska-Kuźnicka Jerzy Chudek Jerzy Chudek Magdalena Olszanecka-Glinianowicz |
| author_sort | Aleksandra Biernacka-Bartnik |
| collection | DOAJ |
| description | IntroductionThe study aimed to estimate the cut-off value for homeostatic model assessment for insulin resistance (HOMA-IR) discriminating the insulin resistance based on the sex hormones binding globulin (SHBG) level in women with polycystic ovary syndrome (PCOS).Materials and methodsData from medical records of 854 Caucasian women diagnosed with PCOS were analyzed. Anthropometric data, fasting plasma glucose, insulin and SHBG levels were measured. HOMA-IR was calculated with a standard formula. The cut-off value was calculated using receiver-operating characteristics.ResultsCirculating SHBG levels below the normal range (26.1 nmol/L) were found in 25.4% of study participants. This subgroup had a significantly higher BMI, fasting glucose and insulin concentrations and HOMA-IR values. Empirical optimal cut-off values for HOMA-IR corresponding to low SHBG levels was ≥2.1 [area under the curve (AUC) 0.73, accuracy 0.65, sensitivity 72.3%, specificity 63.1%, positive predictive value (PPV) 40.0%, negative predictive value (NPV) 87.0%].ConclusionsOur study suggests that the cut-off point for HOMA-IR discriminating the insulin resistance based on the SHBG level, in young Caucasian women with polycystic ovary syndrome is 2.1, and is consistent with the cut-off value adopted by the European Group for the Study of Insulin Resistance (above 2.0). |
| first_indexed | 2024-04-10T04:26:31Z |
| format | Article |
| id | doaj.art-9dc4cf2483334be7b5da20c324122c64 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T04:26:31Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-9dc4cf2483334be7b5da20c324122c642023-03-10T12:05:45ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-03-011010.3389/fmed.2023.11005471100547The cut-off value for HOMA-IR discriminating the insulin resistance based on the SHBG level in women with polycystic ovary syndromeAleksandra Biernacka-Bartnik0Piotr Kocełak1Aleksander Jerzy Owczarek2Piotr Stanisław Choręza3Leszek Markuszewski4Paweł Madej5Monika Puzianowska-Kuźnicka6Monika Puzianowska-Kuźnicka7Jerzy Chudek8Jerzy Chudek9Magdalena Olszanecka-Glinianowicz10Department of Gynecological Endocrinology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, PolandPathophysiology Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, PolandHealth Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, PolandDepartment of Statistics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, PolandFaculty of Medical Sciences and Health Sciences, University of Humanities and Technology in Radom, Radom, PolandDepartment of Gynecological Endocrinology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, PolandDepartment of Human Epigenetics, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, PolandDepartment of Geriatrics and Gerontology, Medical Center of Postgraduate Education, Warsaw, PolandPathophysiology Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, PolandDepartment of Internal Medicine and Oncological Chemotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, PolandHealth Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, PolandIntroductionThe study aimed to estimate the cut-off value for homeostatic model assessment for insulin resistance (HOMA-IR) discriminating the insulin resistance based on the sex hormones binding globulin (SHBG) level in women with polycystic ovary syndrome (PCOS).Materials and methodsData from medical records of 854 Caucasian women diagnosed with PCOS were analyzed. Anthropometric data, fasting plasma glucose, insulin and SHBG levels were measured. HOMA-IR was calculated with a standard formula. The cut-off value was calculated using receiver-operating characteristics.ResultsCirculating SHBG levels below the normal range (26.1 nmol/L) were found in 25.4% of study participants. This subgroup had a significantly higher BMI, fasting glucose and insulin concentrations and HOMA-IR values. Empirical optimal cut-off values for HOMA-IR corresponding to low SHBG levels was ≥2.1 [area under the curve (AUC) 0.73, accuracy 0.65, sensitivity 72.3%, specificity 63.1%, positive predictive value (PPV) 40.0%, negative predictive value (NPV) 87.0%].ConclusionsOur study suggests that the cut-off point for HOMA-IR discriminating the insulin resistance based on the SHBG level, in young Caucasian women with polycystic ovary syndrome is 2.1, and is consistent with the cut-off value adopted by the European Group for the Study of Insulin Resistance (above 2.0).https://www.frontiersin.org/articles/10.3389/fmed.2023.1100547/fullpolycystic ovary syndromeSHBGHOMA-IRcut-off valuereceiver-operating characteristic |
| spellingShingle | Aleksandra Biernacka-Bartnik Piotr Kocełak Aleksander Jerzy Owczarek Piotr Stanisław Choręza Leszek Markuszewski Paweł Madej Monika Puzianowska-Kuźnicka Monika Puzianowska-Kuźnicka Jerzy Chudek Jerzy Chudek Magdalena Olszanecka-Glinianowicz The cut-off value for HOMA-IR discriminating the insulin resistance based on the SHBG level in women with polycystic ovary syndrome Frontiers in Medicine polycystic ovary syndrome SHBG HOMA-IR cut-off value receiver-operating characteristic |
| title | The cut-off value for HOMA-IR discriminating the insulin resistance based on the SHBG level in women with polycystic ovary syndrome |
| title_full | The cut-off value for HOMA-IR discriminating the insulin resistance based on the SHBG level in women with polycystic ovary syndrome |
| title_fullStr | The cut-off value for HOMA-IR discriminating the insulin resistance based on the SHBG level in women with polycystic ovary syndrome |
| title_full_unstemmed | The cut-off value for HOMA-IR discriminating the insulin resistance based on the SHBG level in women with polycystic ovary syndrome |
| title_short | The cut-off value for HOMA-IR discriminating the insulin resistance based on the SHBG level in women with polycystic ovary syndrome |
| title_sort | cut off value for homa ir discriminating the insulin resistance based on the shbg level in women with polycystic ovary syndrome |
| topic | polycystic ovary syndrome SHBG HOMA-IR cut-off value receiver-operating characteristic |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1100547/full |
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