Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities.

Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities.

Osteoporosis is a bone disorder associated with loss of bone mineral density and micro architecture. A balance of osteoblasts and osteoclasts activities maintains bone homeostasis. Increased bone loss due to increased osteoclast and decreased osteoblast activities is considered as an underlying caus...

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Bibliographic Details
Main Authors: Reeva Aggarwal, Jingwei Lu, Suman Kanji, Matthew Joseph, Manjusri Das, Garrett J Noble, Brooke K McMichael, Sudha Agarwal, Richard T Hart, Zongyang Sun, Beth S Lee, Thomas J Rosol, Rebecca Jackson, Hai-Quan Mao, Vincent J Pompili, Hiranmoy Das
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3377665?pdf=render

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