Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck
Mucosal malignant melanoma of the head and neck is a rare diagnosis. The safety and efficacy of salvage neck dissection following carbon−ion radiotherapy with concurrent chemotherapy are not well described, and carbon−ion radiation protocols have not been fully developed. A 77 ye...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/2/82 |
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| author | Hidenori Suzuki Eiichi Sasaki Risa Motai Seiya Goto Daisuke Nishikawa Shintaro Beppu Hoshino Terada Michi Sawabe Nobuhiro Hanai |
| author_facet | Hidenori Suzuki Eiichi Sasaki Risa Motai Seiya Goto Daisuke Nishikawa Shintaro Beppu Hoshino Terada Michi Sawabe Nobuhiro Hanai |
| author_sort | Hidenori Suzuki |
| collection | DOAJ |
| description | Mucosal malignant melanoma of the head and neck is a rare diagnosis. The safety and efficacy of salvage neck dissection following carbon−ion radiotherapy with concurrent chemotherapy are not well described, and carbon−ion radiation protocols have not been fully developed. A 77 year old woman with crT0N1M0 mucosal melanoma of the head and neck achieved a complete response following initial treatment with carbon−ion radiotherapy and concurrent chemotherapy. She was treated with salvage neck dissection for as a cervical lymph node metastasis 16 months after initial treatment. She experienced neither Clavien-Dindo Grade 3 or 4 postoperative complications nor subsequent recurrence of disease at 3 months following salvage neck dissection. Surgical specimens may be useful for future precision oncology based on the molecular biology of recurrence melanoma with poor prognosis. |
| first_indexed | 2024-04-13T00:32:33Z |
| format | Article |
| id | doaj.art-9dc849e5998b40f89784ef9fdc558a8d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-13T00:32:33Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-9dc849e5998b40f89784ef9fdc558a8d2022-12-22T03:10:26ZengMDPI AGDiagnostics2075-44182020-02-011028210.3390/diagnostics10020082diagnostics10020082Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and NeckHidenori Suzuki0Eiichi Sasaki1Risa Motai2Seiya Goto3Daisuke Nishikawa4Shintaro Beppu5Hoshino Terada6Michi Sawabe7Nobuhiro Hanai8Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 464-0021, JapanDepartment of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya 464-0021, JapanDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 464-0021, JapanDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 464-0021, JapanDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 464-0021, JapanDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 464-0021, JapanDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 464-0021, JapanDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 464-0021, JapanDepartment of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya 464-0021, JapanMucosal malignant melanoma of the head and neck is a rare diagnosis. The safety and efficacy of salvage neck dissection following carbon−ion radiotherapy with concurrent chemotherapy are not well described, and carbon−ion radiation protocols have not been fully developed. A 77 year old woman with crT0N1M0 mucosal melanoma of the head and neck achieved a complete response following initial treatment with carbon−ion radiotherapy and concurrent chemotherapy. She was treated with salvage neck dissection for as a cervical lymph node metastasis 16 months after initial treatment. She experienced neither Clavien-Dindo Grade 3 or 4 postoperative complications nor subsequent recurrence of disease at 3 months following salvage neck dissection. Surgical specimens may be useful for future precision oncology based on the molecular biology of recurrence melanoma with poor prognosis.https://www.mdpi.com/2075-4418/10/2/82mucosal malignant melanoma in head and necksalvage neck dissectioncarbon ion radiotherapychemotherapy |
| spellingShingle | Hidenori Suzuki Eiichi Sasaki Risa Motai Seiya Goto Daisuke Nishikawa Shintaro Beppu Hoshino Terada Michi Sawabe Nobuhiro Hanai Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck Diagnostics mucosal malignant melanoma in head and neck salvage neck dissection carbon ion radiotherapy chemotherapy |
| title | Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck |
| title_full | Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck |
| title_fullStr | Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck |
| title_full_unstemmed | Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck |
| title_short | Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck |
| title_sort | safety and efficacy of salvage neck dissection following carbon ion radiotherapy with chemotherapy for a patient with mucosal malignant melanoma of head and neck |
| topic | mucosal malignant melanoma in head and neck salvage neck dissection carbon ion radiotherapy chemotherapy |
| url | https://www.mdpi.com/2075-4418/10/2/82 |
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