Treatment efficacy of 153Sm-EDTMP for painful bone metastasis
Introduction: Involvement of the skeleton can cause an excruciating pain in two-thirds of terminal patients with a history of malignancy. Due to several limitations of other therapies, such as analgesics, bisphosphonates, chemotherapy, hormonal therapy and external beam radiotherapy; bone-seeking ra...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2013-04-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
| Subjects: | |
| Online Access: | http://aojnmb.mums.ac.ir/pdf_602_06cda49f87d515ee6d45bfb525ba1977.html |
| _version_ | 1828775625847996416 |
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| author | Narjess Ayati Kamran Aryana Amir Jalilian Toktam Hoseinnejad Ali Bahrami Samani Zahra Ayati Farzane Shariati Seyed Rasoul Zakavi |
| author_facet | Narjess Ayati Kamran Aryana Amir Jalilian Toktam Hoseinnejad Ali Bahrami Samani Zahra Ayati Farzane Shariati Seyed Rasoul Zakavi |
| author_sort | Narjess Ayati |
| collection | DOAJ |
| description | Introduction: Involvement of the skeleton can cause an excruciating pain in two-thirds of terminal patients with a history of malignancy. Due to several limitations of other therapies, such as analgesics, bisphosphonates, chemotherapy, hormonal therapy and external beam radiotherapy; bone-seeking radiopharmaceuticals have an important role in palliation of pain from bone metastases. Although these kinds of therapies have many advantages including the ability to treat multiple sites of tumoral involvement simultaneously, no significant confliction with other treatments, ease of administration and the potential to be used repetitively; in Iran using of this modality is not widely practiced. In this study we evaluated the clinical usefulness of Sm-153 lexidronamfor pain management of bone metastases. Methods: 28 patients (14 males and 14 females) aged 38-77 years with a history of painful bone metastases caused by different cancers, not responding to conventional treatments were included in the study. All patients had a recent whole body bone scan indicating multiple bone metastases. 1 mCi/Kg Sm-153 lexidronam was injected intravenously to the patients. Whole body scintigraphy was done 3 or 18 hours post injection. Pain relief and quality of life have been evaluated by analog pain scale and Karnofsky index every week, respectively. Also, all patients were evaluated for hematological toxicity every two weeks. Active follow ups were performed. Results: 43% of patients showed the presence of the flare phenomenon during the first three days after Sm injection with a mean duration of 2.2 days. The pain relief began between 2 and 16 days post injection and the duration of pain palliation was in the range of 4 to 32 weeks (mean±SD=15.22±7.8). 64.3% of patients showed complete relief of pain and 21.4% achieved partial response to therapy. (Over all response to therapy was 85.7%). The lowest amount of peripheral blood cells was detected in the fourth week for RBCs and in the 6th week for WBCs and PLTs. No one experienced hematological toxicity induced problems. Conclusion: Sm-153 lexidronam is an effective treatment for painful bone metastases. The complication rate is low and the quality of life of the patients after treatment would be significantly improved. |
| first_indexed | 2024-12-11T15:43:49Z |
| format | Article |
| id | doaj.art-9dc8c5fe91834739bb94adec0780f1e8 |
| institution | Directory Open Access Journal |
| issn | 2322-5718 2322-5726 |
| language | English |
| last_indexed | 2024-12-11T15:43:49Z |
| publishDate | 2013-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj.art-9dc8c5fe91834739bb94adec0780f1e82022-12-22T00:59:45ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262013-04-01112731602Treatment efficacy of 153Sm-EDTMP for painful bone metastasisNarjess Ayati0Kamran Aryana1Amir Jalilian2Toktam Hoseinnejad3Ali Bahrami Samani4Zahra Ayati5Farzane Shariati6Seyed Rasoul Zakavi7Nuclear Medicine Research Center, Mashhad University of Medical Science, Faculty of Medicine, Mashhad, IranNuclear Medicine Research Center, Mashhad University of Medical Science, Faculty of Medicine, Mashhad, IranRadiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, IranNuclear Medicine Research Center, Mashhad University of Medical Science, Faculty of Medicine, Mashhad, IranRadiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, IranSchool of pharmacy, Mashhad University of Medical Science, Mashhad, IranNuclear Medicine Research Center, Mashhad University of Medical Science, Faculty of Medicine, Mashhad, IranNuclear Medicine Research Center, Mashhad University of Medical Science, Faculty of Medicine, Mashhad, IranIntroduction: Involvement of the skeleton can cause an excruciating pain in two-thirds of terminal patients with a history of malignancy. Due to several limitations of other therapies, such as analgesics, bisphosphonates, chemotherapy, hormonal therapy and external beam radiotherapy; bone-seeking radiopharmaceuticals have an important role in palliation of pain from bone metastases. Although these kinds of therapies have many advantages including the ability to treat multiple sites of tumoral involvement simultaneously, no significant confliction with other treatments, ease of administration and the potential to be used repetitively; in Iran using of this modality is not widely practiced. In this study we evaluated the clinical usefulness of Sm-153 lexidronamfor pain management of bone metastases. Methods: 28 patients (14 males and 14 females) aged 38-77 years with a history of painful bone metastases caused by different cancers, not responding to conventional treatments were included in the study. All patients had a recent whole body bone scan indicating multiple bone metastases. 1 mCi/Kg Sm-153 lexidronam was injected intravenously to the patients. Whole body scintigraphy was done 3 or 18 hours post injection. Pain relief and quality of life have been evaluated by analog pain scale and Karnofsky index every week, respectively. Also, all patients were evaluated for hematological toxicity every two weeks. Active follow ups were performed. Results: 43% of patients showed the presence of the flare phenomenon during the first three days after Sm injection with a mean duration of 2.2 days. The pain relief began between 2 and 16 days post injection and the duration of pain palliation was in the range of 4 to 32 weeks (mean±SD=15.22±7.8). 64.3% of patients showed complete relief of pain and 21.4% achieved partial response to therapy. (Over all response to therapy was 85.7%). The lowest amount of peripheral blood cells was detected in the fourth week for RBCs and in the 6th week for WBCs and PLTs. No one experienced hematological toxicity induced problems. Conclusion: Sm-153 lexidronam is an effective treatment for painful bone metastases. The complication rate is low and the quality of life of the patients after treatment would be significantly improved.http://aojnmb.mums.ac.ir/pdf_602_06cda49f87d515ee6d45bfb525ba1977.htmlRadionuclide TherapySamarium153Sm-EDTMPpainful bone metastasis |
| spellingShingle | Narjess Ayati Kamran Aryana Amir Jalilian Toktam Hoseinnejad Ali Bahrami Samani Zahra Ayati Farzane Shariati Seyed Rasoul Zakavi Treatment efficacy of 153Sm-EDTMP for painful bone metastasis Asia Oceania Journal of Nuclear Medicine and Biology Radionuclide Therapy Samarium 153Sm-EDTMP painful bone metastasis |
| title | Treatment efficacy of 153Sm-EDTMP for painful bone metastasis |
| title_full | Treatment efficacy of 153Sm-EDTMP for painful bone metastasis |
| title_fullStr | Treatment efficacy of 153Sm-EDTMP for painful bone metastasis |
| title_full_unstemmed | Treatment efficacy of 153Sm-EDTMP for painful bone metastasis |
| title_short | Treatment efficacy of 153Sm-EDTMP for painful bone metastasis |
| title_sort | treatment efficacy of 153sm edtmp for painful bone metastasis |
| topic | Radionuclide Therapy Samarium 153Sm-EDTMP painful bone metastasis |
| url | http://aojnmb.mums.ac.ir/pdf_602_06cda49f87d515ee6d45bfb525ba1977.html |
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