Successful management of refractory cough with the leukotriene receptor antagonist zafirlukast in a dog with chronic bronchitis: a case report
A 7-year-old spayed female Pomeranian dog was evaluated for a 6-month history of intractable coughing and dyspnoea. The cough was unresponsive to antibiotics and a bronchodilator medication prescribed by the previous animal hospital. No abnormalities were identified on the blood work, echocardiograp...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2018-04-01
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| Series: | Veterinární Medicína |
| Subjects: | |
| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-201804-0005_successful-management-of-refractory-cough-with-the-leukotriene-receptor-antagonist-zafirlukast-in-a-dog-with-ch.php |
| _version_ | 1828006604739444736 |
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| author | I.H. Yoon H.J. Han J.H. Kim |
| author_facet | I.H. Yoon H.J. Han J.H. Kim |
| author_sort | I.H. Yoon |
| collection | DOAJ |
| description | A 7-year-old spayed female Pomeranian dog was evaluated for a 6-month history of intractable coughing and dyspnoea. The cough was unresponsive to antibiotics and a bronchodilator medication prescribed by the previous animal hospital. No abnormalities were identified on the blood work, echocardiography and radiography. However, computed tomography revealed mild bronchiectasia. Based on the history, physical examination and non-specific diagnostic imaging findings, the dog was diagnosed with chronic bronchitis. The cough failed to resolve, despite an attempt to manage it with prednisolone, theophylline, codeine and N-acetylcysteine. With the owner's consent, we stopped all previous medications and finally tried the leukotriene receptor antagonist zafirlukast. The cough progressively improved and had mostly resolved four weeks after starting the administration of zafirlukast. The dog remained in complete remission without recurrence for seven months. This case report is the first to describe the successful long-term management of chronic cough with zafirlukast in a dog. |
| first_indexed | 2024-04-10T07:58:47Z |
| format | Article |
| id | doaj.art-9dcaab8de0f048e09bfd3e1908967deb |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T07:58:47Z |
| publishDate | 2018-04-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-9dcaab8de0f048e09bfd3e1908967deb2023-02-23T03:50:47ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922018-04-0163418118610.17221/162/2017-VETMEDvet-201804-0005Successful management of refractory cough with the leukotriene receptor antagonist zafirlukast in a dog with chronic bronchitis: a case reportI.H. Yoon0H.J. Han1J.H. KimVeterinary Medical Teaching Hospital, Konkuk University, Seoul, Republic of KoreaVeterinary Medical Teaching Hospital, Konkuk University, Seoul, Republic of KoreaA 7-year-old spayed female Pomeranian dog was evaluated for a 6-month history of intractable coughing and dyspnoea. The cough was unresponsive to antibiotics and a bronchodilator medication prescribed by the previous animal hospital. No abnormalities were identified on the blood work, echocardiography and radiography. However, computed tomography revealed mild bronchiectasia. Based on the history, physical examination and non-specific diagnostic imaging findings, the dog was diagnosed with chronic bronchitis. The cough failed to resolve, despite an attempt to manage it with prednisolone, theophylline, codeine and N-acetylcysteine. With the owner's consent, we stopped all previous medications and finally tried the leukotriene receptor antagonist zafirlukast. The cough progressively improved and had mostly resolved four weeks after starting the administration of zafirlukast. The dog remained in complete remission without recurrence for seven months. This case report is the first to describe the successful long-term management of chronic cough with zafirlukast in a dog.https://vetmed.agriculturejournals.cz/artkey/vet-201804-0005_successful-management-of-refractory-cough-with-the-leukotriene-receptor-antagonist-zafirlukast-in-a-dog-with-ch.phpanti-inflammatory medicine; bronchiectasia; canineglucocorticoid-intolerantnon-asthmatic bronchitis |
| spellingShingle | I.H. Yoon H.J. Han J.H. Kim Successful management of refractory cough with the leukotriene receptor antagonist zafirlukast in a dog with chronic bronchitis: a case report Veterinární Medicína anti-inflammatory medicine; bronchiectasia; canine glucocorticoid-intolerant non-asthmatic bronchitis |
| title | Successful management of refractory cough with the leukotriene receptor antagonist zafirlukast in a dog with chronic bronchitis: a case report |
| title_full | Successful management of refractory cough with the leukotriene receptor antagonist zafirlukast in a dog with chronic bronchitis: a case report |
| title_fullStr | Successful management of refractory cough with the leukotriene receptor antagonist zafirlukast in a dog with chronic bronchitis: a case report |
| title_full_unstemmed | Successful management of refractory cough with the leukotriene receptor antagonist zafirlukast in a dog with chronic bronchitis: a case report |
| title_short | Successful management of refractory cough with the leukotriene receptor antagonist zafirlukast in a dog with chronic bronchitis: a case report |
| title_sort | successful management of refractory cough with the leukotriene receptor antagonist zafirlukast in a dog with chronic bronchitis a case report |
| topic | anti-inflammatory medicine; bronchiectasia; canine glucocorticoid-intolerant non-asthmatic bronchitis |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-201804-0005_successful-management-of-refractory-cough-with-the-leukotriene-receptor-antagonist-zafirlukast-in-a-dog-with-ch.php |
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