Biological Properties in Relation to the Health-Promoting Effects of Independent and Combined <i>Garcinia mangostana</i> Pericarp and Curcuma in Lean Wistar Albino Rats
With the increase in verifications and proofs highlighting the association between diet and health, several food products, such as phenolic rich fruits and vegetables, have emerged as possessing potential health benefits. Plants rich with fiber and phenolic content have long been considered as a hea...
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MDPI AG
2023-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/15/8567 |
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| author | Hanan A. Alfawaz Ranyah Shaker M. Labban Ramesa Shafi Bhat Afaf El-Ansary |
| author_facet | Hanan A. Alfawaz Ranyah Shaker M. Labban Ramesa Shafi Bhat Afaf El-Ansary |
| author_sort | Hanan A. Alfawaz |
| collection | DOAJ |
| description | With the increase in verifications and proofs highlighting the association between diet and health, several food products, such as phenolic rich fruits and vegetables, have emerged as possessing potential health benefits. Plants rich with fiber and phenolic content have long been considered as a health-promoting dietary intervention. Therefore, the present work aimed to test the independent and combined potential benefits of mangosteen pericarp extract (MPE) and curcuma rhizome extract (CRE) consumption through an in vivo study on Wister albino rats. The data demonstrated that the three nutritional interventions had no effect on serotonin or glutamate, but dopamine was considerably increased in response to the combined effects of MPE and curcuma (<i>p</i> ˂ 0.025). The anti-inflammatory potency of independent MPE and curcuma, as well as their combined effects, recorded lower levels of IL12 in all groups compared to controls (<i>p</i> ˂ 0.05), and only a considerably lower IL-6 in combination treatment only (<i>p</i> ˂ 0.028). The three dietary interventions dramatically lowered leptin levels, with the combined treatment significantly lower than the healthy control group (<i>p</i> ˂ 0.001). The combined treatment significantly improved levels of malondialdehyde (MDA) and GSH as indicators of oxidative stress and antioxidant capability. Our data reported anti-dyslipidemic and anti-hyperglycemic effects of the three studied nutritional interventions, with the independent curcuma being the most effective anti-hyperglycemic compound (<i>p</i> ˂ 0.009). Collectively, the three used nutritional intervention strategies demonstrated promising health-promoting effects with no side effects. |
| first_indexed | 2024-03-11T00:32:30Z |
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| id | doaj.art-9dcca13a26a0435aacbc4f36480b2181 |
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| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-11T00:32:30Z |
| publishDate | 2023-07-01 |
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| series | Applied Sciences |
| spelling | doaj.art-9dcca13a26a0435aacbc4f36480b21812023-11-18T22:34:35ZengMDPI AGApplied Sciences2076-34172023-07-011315856710.3390/app13158567Biological Properties in Relation to the Health-Promoting Effects of Independent and Combined <i>Garcinia mangostana</i> Pericarp and Curcuma in Lean Wistar Albino RatsHanan A. Alfawaz0Ranyah Shaker M. Labban1Ramesa Shafi Bhat2Afaf El-Ansary3Department of Food Science & Nutrition, College of Food Science & Agriculture, King Saud University, Riyadh 11495, Saudi ArabiaDepartment of Food Science & Nutrition, College of Food Science & Agriculture, King Saud University, Riyadh 11495, Saudi ArabiaBiochemistry Department, College of Science, King Saud University, Riyadh 11495, Saudi ArabiaCentral Research Laboratory, Female Centre for Scientific and Medical Studies, King Saud University, Riyadh 11495, Saudi ArabiaWith the increase in verifications and proofs highlighting the association between diet and health, several food products, such as phenolic rich fruits and vegetables, have emerged as possessing potential health benefits. Plants rich with fiber and phenolic content have long been considered as a health-promoting dietary intervention. Therefore, the present work aimed to test the independent and combined potential benefits of mangosteen pericarp extract (MPE) and curcuma rhizome extract (CRE) consumption through an in vivo study on Wister albino rats. The data demonstrated that the three nutritional interventions had no effect on serotonin or glutamate, but dopamine was considerably increased in response to the combined effects of MPE and curcuma (<i>p</i> ˂ 0.025). The anti-inflammatory potency of independent MPE and curcuma, as well as their combined effects, recorded lower levels of IL12 in all groups compared to controls (<i>p</i> ˂ 0.05), and only a considerably lower IL-6 in combination treatment only (<i>p</i> ˂ 0.028). The three dietary interventions dramatically lowered leptin levels, with the combined treatment significantly lower than the healthy control group (<i>p</i> ˂ 0.001). The combined treatment significantly improved levels of malondialdehyde (MDA) and GSH as indicators of oxidative stress and antioxidant capability. Our data reported anti-dyslipidemic and anti-hyperglycemic effects of the three studied nutritional interventions, with the independent curcuma being the most effective anti-hyperglycemic compound (<i>p</i> ˂ 0.009). Collectively, the three used nutritional intervention strategies demonstrated promising health-promoting effects with no side effects.https://www.mdpi.com/2076-3417/13/15/8567<i>Garcinia mangostana</i> pericarpcurcuma rhizome extract (CRE)inflammationoxidative stressdietary intervention dyslipidemia |
| spellingShingle | Hanan A. Alfawaz Ranyah Shaker M. Labban Ramesa Shafi Bhat Afaf El-Ansary Biological Properties in Relation to the Health-Promoting Effects of Independent and Combined <i>Garcinia mangostana</i> Pericarp and Curcuma in Lean Wistar Albino Rats Applied Sciences <i>Garcinia mangostana</i> pericarp curcuma rhizome extract (CRE) inflammation oxidative stress dietary intervention dyslipidemia |
| title | Biological Properties in Relation to the Health-Promoting Effects of Independent and Combined <i>Garcinia mangostana</i> Pericarp and Curcuma in Lean Wistar Albino Rats |
| title_full | Biological Properties in Relation to the Health-Promoting Effects of Independent and Combined <i>Garcinia mangostana</i> Pericarp and Curcuma in Lean Wistar Albino Rats |
| title_fullStr | Biological Properties in Relation to the Health-Promoting Effects of Independent and Combined <i>Garcinia mangostana</i> Pericarp and Curcuma in Lean Wistar Albino Rats |
| title_full_unstemmed | Biological Properties in Relation to the Health-Promoting Effects of Independent and Combined <i>Garcinia mangostana</i> Pericarp and Curcuma in Lean Wistar Albino Rats |
| title_short | Biological Properties in Relation to the Health-Promoting Effects of Independent and Combined <i>Garcinia mangostana</i> Pericarp and Curcuma in Lean Wistar Albino Rats |
| title_sort | biological properties in relation to the health promoting effects of independent and combined i garcinia mangostana i pericarp and curcuma in lean wistar albino rats |
| topic | <i>Garcinia mangostana</i> pericarp curcuma rhizome extract (CRE) inflammation oxidative stress dietary intervention dyslipidemia |
| url | https://www.mdpi.com/2076-3417/13/15/8567 |
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