Brentuximab vedotin is the first target drug in the treatment of hodgkin lymphoma
Progress in the treatment of Hodgkin lymphoma are among the most significant achievements of oncology of our age. Nevertheless, an early relapse or refractory course of the disease account for approximately 15–20% of cases. It was this category of patients, in which the target drug brentuximab vedot...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2018-11-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/2755 |
| _version_ | 1797842053589106688 |
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| author | G. S. Tumyan |
| author_facet | G. S. Tumyan |
| author_sort | G. S. Tumyan |
| collection | DOAJ |
| description | Progress in the treatment of Hodgkin lymphoma are among the most significant achievements of oncology of our age. Nevertheless, an early relapse or refractory course of the disease account for approximately 15–20% of cases. It was this category of patients, in which the target drug brentuximab vedotin was successfully used for the first time. This is an anti-CD30 (a cell surface antigen) humanized monoclonal antibody conjugated via a protease-cleavable linker to the cytostatic agent monomethyl auristatin E, the potent tubulin inhibitor. This article describes the characteristics of CD30 antigen and a new preparation, as well as clinical data confirming its efficacy, the results of major reviews and research on the use of brentuximab vedotin in mono and combination therapy regimens at the different stages of treatment for Hodgkin lymphoma. |
| first_indexed | 2024-04-09T16:41:37Z |
| format | Article |
| id | doaj.art-9dccea35a0a24ffab5bf5c50e95ffa9b |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:41:37Z |
| publishDate | 2018-11-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-9dccea35a0a24ffab5bf5c50e95ffa9b2023-04-23T06:56:40ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902018-11-0101910110510.21518/2079-701X-2018-19-101-1052697Brentuximab vedotin is the first target drug in the treatment of hodgkin lymphomaG. S. Tumyan0Blokhin Russian Cancer Research Center of the Ministry of Health of Russia, MoscowProgress in the treatment of Hodgkin lymphoma are among the most significant achievements of oncology of our age. Nevertheless, an early relapse or refractory course of the disease account for approximately 15–20% of cases. It was this category of patients, in which the target drug brentuximab vedotin was successfully used for the first time. This is an anti-CD30 (a cell surface antigen) humanized monoclonal antibody conjugated via a protease-cleavable linker to the cytostatic agent monomethyl auristatin E, the potent tubulin inhibitor. This article describes the characteristics of CD30 antigen and a new preparation, as well as clinical data confirming its efficacy, the results of major reviews and research on the use of brentuximab vedotin in mono and combination therapy regimens at the different stages of treatment for Hodgkin lymphoma.https://www.med-sovet.pro/jour/article/view/2755hodgkin lymphomacd30 antigenbrentuximab vedotin |
| spellingShingle | G. S. Tumyan Brentuximab vedotin is the first target drug in the treatment of hodgkin lymphoma Медицинский совет hodgkin lymphoma cd30 antigen brentuximab vedotin |
| title | Brentuximab vedotin is the first target drug in the treatment of hodgkin lymphoma |
| title_full | Brentuximab vedotin is the first target drug in the treatment of hodgkin lymphoma |
| title_fullStr | Brentuximab vedotin is the first target drug in the treatment of hodgkin lymphoma |
| title_full_unstemmed | Brentuximab vedotin is the first target drug in the treatment of hodgkin lymphoma |
| title_short | Brentuximab vedotin is the first target drug in the treatment of hodgkin lymphoma |
| title_sort | brentuximab vedotin is the first target drug in the treatment of hodgkin lymphoma |
| topic | hodgkin lymphoma cd30 antigen brentuximab vedotin |
| url | https://www.med-sovet.pro/jour/article/view/2755 |
| work_keys_str_mv | AT gstumyan brentuximabvedotinisthefirsttargetdruginthetreatmentofhodgkinlymphoma |