Exploring the human microbiome – A step forward for precision medicine in breast cancer
Abstract Background The second most frequent cancer in the world and the most common malignancy in women is breast cancer. Breast cancer is a significant health concern in India with a high mortality‐to‐incidence ratio and presentation at a younger age. Recent Findings Recent studies have identified...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.1877 |
| _version_ | 1797628183544070144 |
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| author | Asmita Jotshi Krishna Kishore Sukla Mohammed Monzoorul Haque Chandrani Bose Binuja Varma C. B. Koppiker Sneha Joshi Rupa Mishra |
| author_facet | Asmita Jotshi Krishna Kishore Sukla Mohammed Monzoorul Haque Chandrani Bose Binuja Varma C. B. Koppiker Sneha Joshi Rupa Mishra |
| author_sort | Asmita Jotshi |
| collection | DOAJ |
| description | Abstract Background The second most frequent cancer in the world and the most common malignancy in women is breast cancer. Breast cancer is a significant health concern in India with a high mortality‐to‐incidence ratio and presentation at a younger age. Recent Findings Recent studies have identified gut microbiota as a significant factor that can have an influence on the development, treatment, and prognosis of breast cancer. This review article aims to describe the influence of microbial dysbiosis on breast cancer occurrence and the possible interactions between oncobiome and specific breast cancer molecular subtypes. The review further also discusses the role of epigenetics and diet/nutrition in the regulation of the gut and breast microbiome and its association with breast cancer prevention, therapy, and recurrence. Additionally, the recent technological advances in microbiome research, including next‐generation sequencing (NGS) technologies, genome sequencing, single‐cell sequencing, and microbial metabolomics along with recent advances in artificial intelligence (AI) have also been reviewed. This is an attempt to present a comprehensive status of the microbiome as a key cancer biomarker. Conclusion We believe that correlating microbiome and carcinogenesis is important as it can provide insights into the mechanisms by which microbial dysbiosis can influence cancer development and progression, leading to the potential use of the microbiome as a tool for prognostication and personalized therapy. |
| first_indexed | 2024-03-11T10:34:47Z |
| format | Article |
| id | doaj.art-9dcd4df11b91446e8b86dc004af2180d |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-03-11T10:34:47Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-9dcd4df11b91446e8b86dc004af2180d2023-11-14T11:25:35ZengWileyCancer Reports2573-83482023-11-01611n/an/a10.1002/cnr2.1877Exploring the human microbiome – A step forward for precision medicine in breast cancerAsmita Jotshi0Krishna Kishore Sukla1Mohammed Monzoorul Haque2Chandrani Bose3Binuja Varma4C. B. Koppiker5Sneha Joshi6Rupa Mishra7Centre for Translational Cancer Research: A Joint Initiative of Indian Institute of Science Education and Research (IISER) Pune and Prashanti Cancer Care Mission (PCCM) Pune IndiaLife Sciences R&D, TCS Research, Tata Consultancy Services Limited Pune IndiaLife Sciences R&D, TCS Research, Tata Consultancy Services Limited Pune IndiaLife Sciences R&D, TCS Research, Tata Consultancy Services Limited Pune IndiaTCS Genomics Lab, Tata Consultancy Services Limited New Delhi IndiaCentre for Translational Cancer Research: A Joint Initiative of Indian Institute of Science Education and Research (IISER) Pune and Prashanti Cancer Care Mission (PCCM) Pune IndiaCentre for Translational Cancer Research: A Joint Initiative of Indian Institute of Science Education and Research (IISER) Pune and Prashanti Cancer Care Mission (PCCM) Pune IndiaCentre for Translational Cancer Research: A Joint Initiative of Indian Institute of Science Education and Research (IISER) Pune and Prashanti Cancer Care Mission (PCCM) Pune IndiaAbstract Background The second most frequent cancer in the world and the most common malignancy in women is breast cancer. Breast cancer is a significant health concern in India with a high mortality‐to‐incidence ratio and presentation at a younger age. Recent Findings Recent studies have identified gut microbiota as a significant factor that can have an influence on the development, treatment, and prognosis of breast cancer. This review article aims to describe the influence of microbial dysbiosis on breast cancer occurrence and the possible interactions between oncobiome and specific breast cancer molecular subtypes. The review further also discusses the role of epigenetics and diet/nutrition in the regulation of the gut and breast microbiome and its association with breast cancer prevention, therapy, and recurrence. Additionally, the recent technological advances in microbiome research, including next‐generation sequencing (NGS) technologies, genome sequencing, single‐cell sequencing, and microbial metabolomics along with recent advances in artificial intelligence (AI) have also been reviewed. This is an attempt to present a comprehensive status of the microbiome as a key cancer biomarker. Conclusion We believe that correlating microbiome and carcinogenesis is important as it can provide insights into the mechanisms by which microbial dysbiosis can influence cancer development and progression, leading to the potential use of the microbiome as a tool for prognostication and personalized therapy.https://doi.org/10.1002/cnr2.1877AI/MLbiomarkerbreast cancermicrobiomeoncobiomeprecision oncology |
| spellingShingle | Asmita Jotshi Krishna Kishore Sukla Mohammed Monzoorul Haque Chandrani Bose Binuja Varma C. B. Koppiker Sneha Joshi Rupa Mishra Exploring the human microbiome – A step forward for precision medicine in breast cancer Cancer Reports AI/ML biomarker breast cancer microbiome oncobiome precision oncology |
| title | Exploring the human microbiome – A step forward for precision medicine in breast cancer |
| title_full | Exploring the human microbiome – A step forward for precision medicine in breast cancer |
| title_fullStr | Exploring the human microbiome – A step forward for precision medicine in breast cancer |
| title_full_unstemmed | Exploring the human microbiome – A step forward for precision medicine in breast cancer |
| title_short | Exploring the human microbiome – A step forward for precision medicine in breast cancer |
| title_sort | exploring the human microbiome a step forward for precision medicine in breast cancer |
| topic | AI/ML biomarker breast cancer microbiome oncobiome precision oncology |
| url | https://doi.org/10.1002/cnr2.1877 |
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