Photocurable hydrogel-elastomer hybrids as an adhesive patch for meniscus repair
Hydrogel adhesives are gaining popularity in tissue engineering and regeneration medicine. However, unsatisfactory anti-tension properties of traditional hydrogels limit their practical uses, particularly in sports medicine, which usually requires robust mechanical properties. Here, we design a tiss...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523003301 |
| _version_ | 1827968629158707200 |
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| author | Tao Lei Yushuang Zhao Xinrang Zhai Shunxian Ji Binghua Song Wei Dong Chong Teng Wei Wei |
| author_facet | Tao Lei Yushuang Zhao Xinrang Zhai Shunxian Ji Binghua Song Wei Dong Chong Teng Wei Wei |
| author_sort | Tao Lei |
| collection | DOAJ |
| description | Hydrogel adhesives are gaining popularity in tissue engineering and regeneration medicine. However, unsatisfactory anti-tension properties of traditional hydrogels limit their practical uses, particularly in sports medicine, which usually requires robust mechanical properties. Here, we design a tissue adhesive patch based on a bioadhesive hydrogel (HAMA-GelNB) and a tough elastomer (PDMS) that can atraumatically and rapidly repair tissue injuries such as meniscus tears. The strong and sutureless sealing capabilities of the hybrids are demonstrated using ex vivo porcine skin and stomach models. In vitro cell studies and in vivo subcutaneous implantation models are used and demonstrated the biocompatibility of the material. Finally, the efficiency of the tissue adhesive patch is demonstrated using a rabbit meniscus tear model which is challenging in clinic. The results of macroscopic images and histological analysis revealed that the surface of cartilage in the material-treated group was slightly worn, but the untreated group developed progressive cartilage degeneration. These findings demonstrate that the hydrogel-elastomer composite tissue adhesive could be an alternative to sutures for tissue repair and is promising in translational medicine. |
| first_indexed | 2024-04-09T18:24:34Z |
| format | Article |
| id | doaj.art-9dd0c798363a431aa2cabefcd71c4235 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-09T18:24:34Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
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| series | Materials & Design |
| spelling | doaj.art-9dd0c798363a431aa2cabefcd71c42352023-04-12T04:11:33ZengElsevierMaterials & Design0264-12752023-05-01229111915Photocurable hydrogel-elastomer hybrids as an adhesive patch for meniscus repairTao Lei0Yushuang Zhao1Xinrang Zhai2Shunxian Ji3Binghua Song4Wei Dong5Chong Teng6Wei Wei7Department of Orthopaedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, ChinaDepartment of Orthopaedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, China; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, ChinaDepartment of Orthopaedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, China; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, ChinaDepartment of Orthopaedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, ChinaDepartment of Orthopaedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, ChinaSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China; Corresponding authors at: Department of Orthopaedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, China (W. Wei).Department of Orthopaedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, China; Corresponding authors at: Department of Orthopaedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, China (W. Wei).Department of Orthopaedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, China; Corresponding authors at: Department of Orthopaedic Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang 322000, China (W. Wei).Hydrogel adhesives are gaining popularity in tissue engineering and regeneration medicine. However, unsatisfactory anti-tension properties of traditional hydrogels limit their practical uses, particularly in sports medicine, which usually requires robust mechanical properties. Here, we design a tissue adhesive patch based on a bioadhesive hydrogel (HAMA-GelNB) and a tough elastomer (PDMS) that can atraumatically and rapidly repair tissue injuries such as meniscus tears. The strong and sutureless sealing capabilities of the hybrids are demonstrated using ex vivo porcine skin and stomach models. In vitro cell studies and in vivo subcutaneous implantation models are used and demonstrated the biocompatibility of the material. Finally, the efficiency of the tissue adhesive patch is demonstrated using a rabbit meniscus tear model which is challenging in clinic. The results of macroscopic images and histological analysis revealed that the surface of cartilage in the material-treated group was slightly worn, but the untreated group developed progressive cartilage degeneration. These findings demonstrate that the hydrogel-elastomer composite tissue adhesive could be an alternative to sutures for tissue repair and is promising in translational medicine.http://www.sciencedirect.com/science/article/pii/S0264127523003301HydrogelElastomerTough tissue adhesiveTissue repairTranslational medicine |
| spellingShingle | Tao Lei Yushuang Zhao Xinrang Zhai Shunxian Ji Binghua Song Wei Dong Chong Teng Wei Wei Photocurable hydrogel-elastomer hybrids as an adhesive patch for meniscus repair Materials & Design Hydrogel Elastomer Tough tissue adhesive Tissue repair Translational medicine |
| title | Photocurable hydrogel-elastomer hybrids as an adhesive patch for meniscus repair |
| title_full | Photocurable hydrogel-elastomer hybrids as an adhesive patch for meniscus repair |
| title_fullStr | Photocurable hydrogel-elastomer hybrids as an adhesive patch for meniscus repair |
| title_full_unstemmed | Photocurable hydrogel-elastomer hybrids as an adhesive patch for meniscus repair |
| title_short | Photocurable hydrogel-elastomer hybrids as an adhesive patch for meniscus repair |
| title_sort | photocurable hydrogel elastomer hybrids as an adhesive patch for meniscus repair |
| topic | Hydrogel Elastomer Tough tissue adhesive Tissue repair Translational medicine |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523003301 |
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