Differential MMP-14 Targeting by Lumican-Derived Peptides Unraveled by In Silico Approach

Differential MMP-14 Targeting by Lumican-Derived Peptides Unraveled by In Silico Approach

Lumican, a small leucine-rich proteoglycan (SLRP) of the extracellular matrix (ECM), displays anti-tumor properties through its direct interaction with MMP-14. Lumican-derived peptides, such as lumcorin (17 amino acids) or L9M (10 amino acids), are able to inhibit the proteolytic activity of MMP-14...

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Bibliographic Details
Main Authors: Jonathan Dauvé, Nicolas Belloy, Romain Rivet, Nicolas Etique, Pierre Nizet, Katarzyna Pietraszek-Gremplewicz, Konstantina Karamanou, Manuel Dauchez, Laurent Ramont, Stéphane Brézillon, Stéphanie Baud
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
MMP-14
lumican
in silico approach
molecular docking
dynamics
melanoma
Online Access:https://www.mdpi.com/2072-6694/13/19/4930

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