Leveraging structural and 2D-QSAR to investigate the role of functional group substitutions, conserved surface residues and desolvation in triggering the small molecule-induced dimerization of hPD-L1
Abstract Small molecules are rising as a new generation of immune checkpoints’ inhibitors, with compounds targeting the human Programmed death-ligand 1 (hPD-L1) protein are pioneering this area of research. Promising examples include the recently disclosed compounds from Bristol-Myers-Squibb (BMS)....
Main Authors: | Marawan Ahmed, Aravindhan Ganesan, Khaled Barakat |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-06-01
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Series: | BMC Chemistry |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13065-022-00842-w |
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