Does Selection for Longevity in <i>Acheta domesticus</i> Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)?
Sirtuins, often called “longevity enzymes”, are pivotal in genome protection and DNA repair processes, offering insights into aging and longevity. This study delves into the potential impact of resveratrol (RV) and nanodiamonds (NDs) on sirtuin activity, focusing on two strains of house crickets (&l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/2/1329 |
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| author | Patrycja Ziętara Barbara Flasz Maria Augustyniak |
| author_facet | Patrycja Ziętara Barbara Flasz Maria Augustyniak |
| author_sort | Patrycja Ziętara |
| collection | DOAJ |
| description | Sirtuins, often called “longevity enzymes”, are pivotal in genome protection and DNA repair processes, offering insights into aging and longevity. This study delves into the potential impact of resveratrol (RV) and nanodiamonds (NDs) on sirtuin activity, focusing on two strains of house crickets (<i>Acheta domesticus</i>): the wild-type and long-lived strains. The general sirtuin activity was measured using colorimetric assays, while fluorescence assays assessed SIRT1 activity. Additionally, a DNA damage test and a Kaplan–Meier survival analysis were carried out. Experimental groups were fed diets containing either NDs or RV. Notably, the long-lived strain exhibited significantly higher sirtuin activity compared to the wild-type strain. Interestingly, this heightened sirtuin activity persisted even after exposure to RVs and NDs. These findings indicate that RV and NDs can potentially enhance sirtuin activity in house crickets, with a notable impact on the long-lived strain. This research sheds light on the intriguing potential of RV and NDs as sirtuin activators in house crickets. It might be a milestone for future investigations into sirtuin activity and its potential implications for longevity within the same species, laying the groundwork for broader applications in aging and lifespan extension research. |
| first_indexed | 2024-03-08T09:52:08Z |
| format | Article |
| id | doaj.art-9dd1a9ed7db44c9faa6b141fcf1c1849 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T09:52:08Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9dd1a9ed7db44c9faa6b141fcf1c18492024-01-29T13:59:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-01252132910.3390/ijms25021329Does Selection for Longevity in <i>Acheta domesticus</i> Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)?Patrycja Ziętara0Barbara Flasz1Maria Augustyniak2Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, ul. Bankowa 9, 40-007 Katowice, PolandFaculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, ul. Bankowa 9, 40-007 Katowice, PolandFaculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, ul. Bankowa 9, 40-007 Katowice, PolandSirtuins, often called “longevity enzymes”, are pivotal in genome protection and DNA repair processes, offering insights into aging and longevity. This study delves into the potential impact of resveratrol (RV) and nanodiamonds (NDs) on sirtuin activity, focusing on two strains of house crickets (<i>Acheta domesticus</i>): the wild-type and long-lived strains. The general sirtuin activity was measured using colorimetric assays, while fluorescence assays assessed SIRT1 activity. Additionally, a DNA damage test and a Kaplan–Meier survival analysis were carried out. Experimental groups were fed diets containing either NDs or RV. Notably, the long-lived strain exhibited significantly higher sirtuin activity compared to the wild-type strain. Interestingly, this heightened sirtuin activity persisted even after exposure to RVs and NDs. These findings indicate that RV and NDs can potentially enhance sirtuin activity in house crickets, with a notable impact on the long-lived strain. This research sheds light on the intriguing potential of RV and NDs as sirtuin activators in house crickets. It might be a milestone for future investigations into sirtuin activity and its potential implications for longevity within the same species, laying the groundwork for broader applications in aging and lifespan extension research.https://www.mdpi.com/1422-0067/25/2/1329sirtuinslongevityresveratrolnanodiamonds<i>Acheta domesticus</i> |
| spellingShingle | Patrycja Ziętara Barbara Flasz Maria Augustyniak Does Selection for Longevity in <i>Acheta domesticus</i> Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)? International Journal of Molecular Sciences sirtuins longevity resveratrol nanodiamonds <i>Acheta domesticus</i> |
| title | Does Selection for Longevity in <i>Acheta domesticus</i> Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)? |
| title_full | Does Selection for Longevity in <i>Acheta domesticus</i> Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)? |
| title_fullStr | Does Selection for Longevity in <i>Acheta domesticus</i> Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)? |
| title_full_unstemmed | Does Selection for Longevity in <i>Acheta domesticus</i> Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)? |
| title_short | Does Selection for Longevity in <i>Acheta domesticus</i> Involve Sirtuin Activity Modulation and Differential Response to Activators (Resveratrol and Nanodiamonds)? |
| title_sort | does selection for longevity in i acheta domesticus i involve sirtuin activity modulation and differential response to activators resveratrol and nanodiamonds |
| topic | sirtuins longevity resveratrol nanodiamonds <i>Acheta domesticus</i> |
| url | https://www.mdpi.com/1422-0067/25/2/1329 |
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