Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension
Florence Coste,1,2,* Ilyes Benlala,1,2,* Gaël Dournes,1–3 Claire Dromer,3 Elodie Blanchard,3 Pierre-Olivier Girodet,1–3 Michel Montaudon,1–3 Fabien Baldacci,4 François Picard,3 Roger Marthan,1–3 François Laurent,1–3,* P...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2019-02-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/quantitative-ct-assessment-of-bronchial-and-vascular-alterations-in-se-peer-reviewed-article-COPD |
| _version_ | 1819278622269112320 |
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| author | Coste F Benlala I Dournes G Dromer C Blanchard E Girodet PO Montaudon M Baldacci F Picard F Marthan R Laurent F Berger P |
| author_facet | Coste F Benlala I Dournes G Dromer C Blanchard E Girodet PO Montaudon M Baldacci F Picard F Marthan R Laurent F Berger P |
| author_sort | Coste F |
| collection | DOAJ |
| description | Florence Coste,1,2,* Ilyes Benlala,1,2,* Gaël Dournes,1–3 Claire Dromer,3 Elodie Blanchard,3 Pierre-Olivier Girodet,1–3 Michel Montaudon,1–3 Fabien Baldacci,4 François Picard,3 Roger Marthan,1–3 François Laurent,1–3,* Patrick Berger1–3,* 1Université de Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, F-33000 Bordeaux, France; 2Centre de Recherche Cardio-Thoracique de Bordeaux, INSERM, U1045, Université de Bordeaux, CIC1401, F-33000 Bordeaux, France; 3CHU de Bordeaux, Service d’Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service de Cardiologie, CIC1401, Service d’Explorations Fonctionnelles Respiratoires, F-33600 Pessac, France; 4Université de Bordeaux, LaBRI, F-33405 Talence Cedex, France *These authors contributed equally to this work Background: Little is known about in vivo alterations at bronchial and vascular levels in severe pulmonary hypertension (PH) of different etiologies. We aimed to compare quantitative computed tomography (CT) data from the following three groups of severe precapillary PH patients: COPD, idiopathic pulmonary arterial hypertension (iPAH), and chronic thromboembolic PH (CTEPH). Patients and methods: This study was approved by the institutional review board. Severe PH patients (mean pulmonary arterial pressure [mPAP] ≥35 mmHg) with COPD, iPAH, or CTEPH (n=24, 16, or 16, respectively) were included retrospectively between January 2008 and January 2017. Univariate analysis of mPAP was performed in each severe PH group. Bronchial wall thickness (WT) and percentage of cross sectional area of pulmonary vessels less than 5 mm2 normalized by lung area (%CSA<5) were measured and compared using CT, and then combined to arterial partial pressure of oxygen (PaO2) to generate a “paw score” compared within the three groups using Kruskal–Wallis and its sensitivity using Fisher’s exact test. Results: WT was higher and %CSA<5 was lower in the COPD group compared to iPAH and CTEPH groups. Mosaic pattern was higher in CTEPH group than in others. In severe PH patients secondary to COPD, mPAP was positively correlated to %CSA<5. By contrast, in severe iPAH, this correlation was negative, or not correlated in severe CTEPH groups. In the COPD group, “paw score” showed higher sensitivity than in the other two groups. Conclusion: Unlike in severe iPAH and CTEPH, severe PH with COPD can be predicted by “paw score” reflecting bronchial and vascular morphological differential alterations. Keywords: computed tomography, pulmonary hypertension, COPD, prediction, quantitative |
| first_indexed | 2024-12-24T00:14:56Z |
| format | Article |
| id | doaj.art-9dd256880a51460ab2e3d56f0a3fe436 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-24T00:14:56Z |
| publishDate | 2019-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-9dd256880a51460ab2e3d56f0a3fe4362022-12-21T17:24:46ZengDove Medical PressInternational Journal of COPD1178-20052019-02-01Volume 1438138944011Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertensionCoste FBenlala IDournes GDromer CBlanchard EGirodet POMontaudon MBaldacci FPicard FMarthan RLaurent FBerger PFlorence Coste,1,2,* Ilyes Benlala,1,2,* Gaël Dournes,1–3 Claire Dromer,3 Elodie Blanchard,3 Pierre-Olivier Girodet,1–3 Michel Montaudon,1–3 Fabien Baldacci,4 François Picard,3 Roger Marthan,1–3 François Laurent,1–3,* Patrick Berger1–3,* 1Université de Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, F-33000 Bordeaux, France; 2Centre de Recherche Cardio-Thoracique de Bordeaux, INSERM, U1045, Université de Bordeaux, CIC1401, F-33000 Bordeaux, France; 3CHU de Bordeaux, Service d’Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service de Cardiologie, CIC1401, Service d’Explorations Fonctionnelles Respiratoires, F-33600 Pessac, France; 4Université de Bordeaux, LaBRI, F-33405 Talence Cedex, France *These authors contributed equally to this work Background: Little is known about in vivo alterations at bronchial and vascular levels in severe pulmonary hypertension (PH) of different etiologies. We aimed to compare quantitative computed tomography (CT) data from the following three groups of severe precapillary PH patients: COPD, idiopathic pulmonary arterial hypertension (iPAH), and chronic thromboembolic PH (CTEPH). Patients and methods: This study was approved by the institutional review board. Severe PH patients (mean pulmonary arterial pressure [mPAP] ≥35 mmHg) with COPD, iPAH, or CTEPH (n=24, 16, or 16, respectively) were included retrospectively between January 2008 and January 2017. Univariate analysis of mPAP was performed in each severe PH group. Bronchial wall thickness (WT) and percentage of cross sectional area of pulmonary vessels less than 5 mm2 normalized by lung area (%CSA<5) were measured and compared using CT, and then combined to arterial partial pressure of oxygen (PaO2) to generate a “paw score” compared within the three groups using Kruskal–Wallis and its sensitivity using Fisher’s exact test. Results: WT was higher and %CSA<5 was lower in the COPD group compared to iPAH and CTEPH groups. Mosaic pattern was higher in CTEPH group than in others. In severe PH patients secondary to COPD, mPAP was positively correlated to %CSA<5. By contrast, in severe iPAH, this correlation was negative, or not correlated in severe CTEPH groups. In the COPD group, “paw score” showed higher sensitivity than in the other two groups. Conclusion: Unlike in severe iPAH and CTEPH, severe PH with COPD can be predicted by “paw score” reflecting bronchial and vascular morphological differential alterations. Keywords: computed tomography, pulmonary hypertension, COPD, prediction, quantitativehttps://www.dovepress.com/quantitative-ct-assessment-of-bronchial-and-vascular-alterations-in-se-peer-reviewed-article-COPDcomputed tomographypulmonary hypertensionCOPDprediction |
| spellingShingle | Coste F Benlala I Dournes G Dromer C Blanchard E Girodet PO Montaudon M Baldacci F Picard F Marthan R Laurent F Berger P Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension International Journal of COPD computed tomography pulmonary hypertension COPD prediction |
| title | Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension |
| title_full | Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension |
| title_fullStr | Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension |
| title_full_unstemmed | Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension |
| title_short | Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension |
| title_sort | quantitative ct assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension |
| topic | computed tomography pulmonary hypertension COPD prediction |
| url | https://www.dovepress.com/quantitative-ct-assessment-of-bronchial-and-vascular-alterations-in-se-peer-reviewed-article-COPD |
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