Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors

Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors

The CRISPR-associated Cas9 system can modulate disease-causing alleles both in vivo and ex vivo, raising the possibility of therapeutic genome editing. In addition to gene targeting, epigenetic modulation by the catalytically inactive dCas9 may also be a potential form of cancer therapy. Granulin (G...

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Bibliographic Details
Main Authors: Hong Wang, Rui Guo, Zhonghua Du, Ling Bai, Lingyu Li, Jiuwei Cui, Wei Li, Andrew R. Hoffman, Ji-Fan Hu
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
hepatoma
CRISPR dCas9
epigenetic targeting
DNA methylation
histone methylation
DNMT3a
EZH2
KRAB
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253118300039

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http://www.sciencedirect.com/science/article/pii/S2162253118300039

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