TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca2+-Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca2+-Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

Hepatic ischemia–reperfusion (IR) injury is a serious clinical problem that complicates liver resection and transplantation. Despite recent advances in understanding of the pathophysiology of hepatic IR injury, effective interventions and therapeutics are still lacking. Here, we examined the role of...

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Bibliographic Details
Main Authors: Cheng Zhong, Jing Yang, Yiyin Zhang, Xiaoxiao Fan, Yang Fan, Ning Hua, Duguang Li, Shengxi Jin, Yirun Li, Peng Chen, Yongle Chen, Xiaobo Cai, Yi Zhang, Linhua Jiang, Wei Yang, Peilin Yu, Hui Lin
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023-01-01
Series:Research
Online Access:https://spj.science.org/doi/10.34133/research.0159

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