Human papillomavirus and Helicobacter pylori co-infection in gastric cancer patients
Background and Aim: Recent research has highlighted the potential interplay between human papillomavirus (HPV) and Helicobacter pylori (H. pylori) infections in gastric cancer patients. This study aimed to investigate the prevalence of H. pylori and HPV co-infection and its association with tumor ch...
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| Format: | Article |
| Language: | fas |
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Kashan University of Medical Sciences and Health Services
2023-12-01
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| Series: | Fiyz̤ |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-5007-en.pdf |
| _version_ | 1797304081570594816 |
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| author | mohammadreza Pourmohammad Hosseinali Jomeh Mohammadreza khakzad Jina Khayatzadeh Elham Mokhtari Amirmajdi |
| author_facet | mohammadreza Pourmohammad Hosseinali Jomeh Mohammadreza khakzad Jina Khayatzadeh Elham Mokhtari Amirmajdi |
| author_sort | mohammadreza Pourmohammad |
| collection | DOAJ |
| description | Background and Aim: Recent research has highlighted the potential interplay between human papillomavirus (HPV) and Helicobacter pylori (H. pylori) infections in gastric cancer patients. This study aimed to investigate the prevalence of H. pylori and HPV co-infection and its association with tumor characteristics in individuals diagnosed with gastric cancer.
Methods: In this descriptive study, 32 gastric cancer tissue samples and 32 healthy gastric tissue samples were collected from people referred to a hospital in Iran. DNA extraction was performed using a Biogen kit, and Real-time PCR was utilized to detect HPV and H. pylori infections through L1 and cagA gene primers, respectively.
Results: Over 50% of the cancer samples were classified as stage III. Helicobacter pylori infection was detected in 26 cancer tissues (81.2%) and 22 healthy tissues (67.8%). Additionally, four cancer tissue samples (12.5%) tested positive for HPV infection, while no HPV infection cases were observed in the control group. A significant association was found between H. pylori infection and various tumor characteristics, including staging, grade, tumor size, lymph node involvement, and histology in gastric cancer patients. Moreover, HPV infection showed a significant correlation with gastric cancer staging. However, no significant relationship was observed between the co-infection of H. pylori and HPV with gastric cancer.
Conclusion: The study results did not reveal a significant association between the co-infection of H. pylori and HPV with gastric cancer. Nevertheless, a notable relationship between H. pylori and HPV co-infection and gastric cancer staging was observed, highlighting the complexity of interactions between these infectious agents in gastric carcinogenesis. |
| first_indexed | 2024-03-08T00:03:14Z |
| format | Article |
| id | doaj.art-9dd6362e1e7e43cd8ea2ede9a48a31f4 |
| institution | Directory Open Access Journal |
| issn | 1029-7855 2008-9821 |
| language | fas |
| last_indexed | 2024-03-08T00:03:14Z |
| publishDate | 2023-12-01 |
| publisher | Kashan University of Medical Sciences and Health Services |
| record_format | Article |
| series | Fiyz̤ |
| spelling | doaj.art-9dd6362e1e7e43cd8ea2ede9a48a31f42024-02-17T16:31:06ZfasKashan University of Medical Sciences and Health ServicesFiyz̤1029-78552008-98212023-12-01276679687Human papillomavirus and Helicobacter pylori co-infection in gastric cancer patientsmohammadreza Pourmohammad0Hosseinali Jomeh1Mohammadreza khakzad2Jina Khayatzadeh3Elham Mokhtari Amirmajdi4 Department of Medical Parasitology, Faculty of Paramedicine, Ilam University of Medical Sciences, Ilam, Iran Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran Department of Immunology, Mashhad Branch, Islamic Azad University, Mashhad, Iran Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran Department of Internal Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran Background and Aim: Recent research has highlighted the potential interplay between human papillomavirus (HPV) and Helicobacter pylori (H. pylori) infections in gastric cancer patients. This study aimed to investigate the prevalence of H. pylori and HPV co-infection and its association with tumor characteristics in individuals diagnosed with gastric cancer. Methods: In this descriptive study, 32 gastric cancer tissue samples and 32 healthy gastric tissue samples were collected from people referred to a hospital in Iran. DNA extraction was performed using a Biogen kit, and Real-time PCR was utilized to detect HPV and H. pylori infections through L1 and cagA gene primers, respectively. Results: Over 50% of the cancer samples were classified as stage III. Helicobacter pylori infection was detected in 26 cancer tissues (81.2%) and 22 healthy tissues (67.8%). Additionally, four cancer tissue samples (12.5%) tested positive for HPV infection, while no HPV infection cases were observed in the control group. A significant association was found between H. pylori infection and various tumor characteristics, including staging, grade, tumor size, lymph node involvement, and histology in gastric cancer patients. Moreover, HPV infection showed a significant correlation with gastric cancer staging. However, no significant relationship was observed between the co-infection of H. pylori and HPV with gastric cancer. Conclusion: The study results did not reveal a significant association between the co-infection of H. pylori and HPV with gastric cancer. Nevertheless, a notable relationship between H. pylori and HPV co-infection and gastric cancer staging was observed, highlighting the complexity of interactions between these infectious agents in gastric carcinogenesis.http://feyz.kaums.ac.ir/article-1-5007-en.pdfhelicobacter pylorihuman papillomavirusstomach neoplasmsreal-time pcr |
| spellingShingle | mohammadreza Pourmohammad Hosseinali Jomeh Mohammadreza khakzad Jina Khayatzadeh Elham Mokhtari Amirmajdi Human papillomavirus and Helicobacter pylori co-infection in gastric cancer patients Fiyz̤ helicobacter pylori human papillomavirus stomach neoplasms real-time pcr |
| title | Human papillomavirus and Helicobacter pylori co-infection in gastric cancer patients |
| title_full | Human papillomavirus and Helicobacter pylori co-infection in gastric cancer patients |
| title_fullStr | Human papillomavirus and Helicobacter pylori co-infection in gastric cancer patients |
| title_full_unstemmed | Human papillomavirus and Helicobacter pylori co-infection in gastric cancer patients |
| title_short | Human papillomavirus and Helicobacter pylori co-infection in gastric cancer patients |
| title_sort | human papillomavirus and helicobacter pylori co infection in gastric cancer patients |
| topic | helicobacter pylori human papillomavirus stomach neoplasms real-time pcr |
| url | http://feyz.kaums.ac.ir/article-1-5007-en.pdf |
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