Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort
Cadmium (Cd) is a toxic metal associated with adverse health effects, including kidney injury or disease. The aims of this study were to estimate dietary Cd exposure during childhood, and to evaluate the association of early-life dietary Cd with biomarkers of glomerular kidney function in 9-year-old...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/8/4/83 |
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| author | Edna Rodríguez-López Marcela Tamayo-Ortiz Ana Carolina Ariza Eduardo Ortiz-Panozo Andrea L. Deierlein Ivan Pantic Mari Cruz Tolentino Guadalupe Estrada-Gutiérrez Sandra Parra-Hernández Aurora Espejel-Núñez Martha María Téllez-Rojo Robert O. Wright Alison P. Sanders |
| author_facet | Edna Rodríguez-López Marcela Tamayo-Ortiz Ana Carolina Ariza Eduardo Ortiz-Panozo Andrea L. Deierlein Ivan Pantic Mari Cruz Tolentino Guadalupe Estrada-Gutiérrez Sandra Parra-Hernández Aurora Espejel-Núñez Martha María Téllez-Rojo Robert O. Wright Alison P. Sanders |
| author_sort | Edna Rodríguez-López |
| collection | DOAJ |
| description | Cadmium (Cd) is a toxic metal associated with adverse health effects, including kidney injury or disease. The aims of this study were to estimate dietary Cd exposure during childhood, and to evaluate the association of early-life dietary Cd with biomarkers of glomerular kidney function in 9-year-old Mexican children. Our study included 601 children from the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort with up to five follow-up food frequency questionnaires from 1 to 9 years of age; and 480 children with measures of serum creatinine, cystatin C, and blood nitrogen urea (BUN), as well as 9-year-old estimated glomerular filtration rate. Dietary Cd was estimated through food composition tables. Multiple linear regression models were used to analyze the association between 1 and 9 years, cumulative dietary Cd, and each kidney parameter. Dietary Cd exposure increased with age and exceeded the tolerable weekly intake (TWI = 2.5 µg/kg body weight) by 16–64% at all ages. Early-life dietary Cd exposure was above the TWI and we observed inverse associations between dietary Cd exposure and kidney function parameters. Additional studies are needed to assess kidney function trajectories through adolescence. Identifying preventable risk factors including environmental exposures in early life can contribute to decreasing the incidence of adult kidney disease. |
| first_indexed | 2024-03-10T15:49:01Z |
| format | Article |
| id | doaj.art-9dd667921c0a4c2db59470df652399de |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T15:49:01Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-9dd667921c0a4c2db59470df652399de2023-11-20T16:14:53ZengMDPI AGToxics2305-63042020-10-01848310.3390/toxics8040083Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS CohortEdna Rodríguez-López0Marcela Tamayo-Ortiz1Ana Carolina Ariza2Eduardo Ortiz-Panozo3Andrea L. Deierlein4Ivan Pantic5Mari Cruz Tolentino6Guadalupe Estrada-Gutiérrez7Sandra Parra-Hernández8Aurora Espejel-Núñez9Martha María Téllez-Rojo10Robert O. Wright11Alison P. Sanders12Center for Nutrition and Health Research, National Institute of Public Health (INSP), Cuernavaca 62100, Morelos, MexicoCenter for Nutrition and Health Research, National Institute of Public Health (INSP), Cuernavaca 62100, Morelos, MexicoCenter for Nutrition and Health Research, National Institute of Public Health (INSP), Cuernavaca 62100, Morelos, MexicoCenter for Population Health Research, National Institute of Public Health (INSP), Cuernavaca 62100, Morelos, MexicoPublic Health Nutrition, School of Global Public Health, New York University, New York, NY 10012, USADepartment of Developmental Neurobiology, National Institute of Perinatology, Mexico City 11000, MexicoDepartment of Nutrition and Bio programming, National Institute of Perinatology, Mexico City 11000, MexicoDepartment of Immunobiochemistry, National Institute of Perinatology, Mexico City 11000, MexicoDepartment of Immunobiochemistry, National Institute of Perinatology, Mexico City 11000, MexicoDepartment of Immunobiochemistry, National Institute of Perinatology, Mexico City 11000, MexicoCenter for Nutrition and Health Research, National Institute of Public Health (INSP), Cuernavaca 62100, Morelos, MexicoDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USACadmium (Cd) is a toxic metal associated with adverse health effects, including kidney injury or disease. The aims of this study were to estimate dietary Cd exposure during childhood, and to evaluate the association of early-life dietary Cd with biomarkers of glomerular kidney function in 9-year-old Mexican children. Our study included 601 children from the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort with up to five follow-up food frequency questionnaires from 1 to 9 years of age; and 480 children with measures of serum creatinine, cystatin C, and blood nitrogen urea (BUN), as well as 9-year-old estimated glomerular filtration rate. Dietary Cd was estimated through food composition tables. Multiple linear regression models were used to analyze the association between 1 and 9 years, cumulative dietary Cd, and each kidney parameter. Dietary Cd exposure increased with age and exceeded the tolerable weekly intake (TWI = 2.5 µg/kg body weight) by 16–64% at all ages. Early-life dietary Cd exposure was above the TWI and we observed inverse associations between dietary Cd exposure and kidney function parameters. Additional studies are needed to assess kidney function trajectories through adolescence. Identifying preventable risk factors including environmental exposures in early life can contribute to decreasing the incidence of adult kidney disease.https://www.mdpi.com/2305-6304/8/4/83cadmiumchildrendietkidney function |
| spellingShingle | Edna Rodríguez-López Marcela Tamayo-Ortiz Ana Carolina Ariza Eduardo Ortiz-Panozo Andrea L. Deierlein Ivan Pantic Mari Cruz Tolentino Guadalupe Estrada-Gutiérrez Sandra Parra-Hernández Aurora Espejel-Núñez Martha María Téllez-Rojo Robert O. Wright Alison P. Sanders Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort Toxics cadmium children diet kidney function |
| title | Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort |
| title_full | Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort |
| title_fullStr | Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort |
| title_full_unstemmed | Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort |
| title_short | Early-Life Dietary Cadmium Exposure and Kidney Function in 9-Year-Old Children from the PROGRESS Cohort |
| title_sort | early life dietary cadmium exposure and kidney function in 9 year old children from the progress cohort |
| topic | cadmium children diet kidney function |
| url | https://www.mdpi.com/2305-6304/8/4/83 |
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